Increased brain white matter axial diffusivity associated with fatigue, pain and hyperalgesia in Gulf War illness.

MedStar author(s):
Citation: PLoS ONE [Electronic Resource]. 8(3):e58493, 2013.PMID: 23526988Institution: MedStar Washington Hospital CenterDepartment: Medicine/RheumatologyForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, U.S. Gov't, Non-P.H.S.Subject headings: *Brain/pa [Pathology] | *Persian Gulf Syndrome/pa [Pathology] | *Persian Gulf Syndrome/pp [Physiopathology] | Adult | Case-Control Studies | Diffusion Tensor Imaging | Fatigue/pp [Physiopathology] | Female | Humans | Hyperalgesia/pp [Physiopathology] | Male | Middle Aged | Pain/pp [Physiopathology] | VeteransYear: 2013Local holdings: Available online through MWHC library: 2006 - presentISSN:
  • 1932-6203
Name of journal: PloS oneAbstract: BACKGROUND: Gulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction.CONCLUSION: The right inferior fronto-occipital fasciculus may be a potential biomarker for Gulf War Illness. This tract links cortical regions involved in fatigue, pain, emotional and reward processing, and the right ventral attention network in cognition. The axonal neuropathological mechanism(s) explaining increased axial diffusivity may account for the most prominent symptoms of Gulf War Illness.METHODS: Gulf War veterans (n=31) and sedentary veteran and civilian controls (n=20) completed fMRI scans for diffusion tensor imaging. A combination of dolorimetry, subjective reports of pain and fatigue were correlated to white matter diffusivity properties to identify tracts associated with symptom constructs.RESULTS: Gulf War Illness subjects had significantly correlated fatigue, pain, hyperalgesia, and increased axial diffusivity in the right inferior fronto-occipital fasciculus. ROC generated thresholds and subsequent binary regression analysis predicted CMI classification based upon axial diffusivity in the right inferior fronto-occipital fasciculus. These correlates were absent for controls in dichotomous regression analysis.All authors: Adewuyi O, Baraniuk JN, Rayhan RU, Stevens BW, Timbol CR, VanMeter JW, Walitt BFiscal year: FY2014Digital Object Identifier: Date added to catalog: 2013-12-24
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 23526988 Available 23526988

Available online through MWHC library: 2006 - present

BACKGROUND: Gulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction.

CONCLUSION: The right inferior fronto-occipital fasciculus may be a potential biomarker for Gulf War Illness. This tract links cortical regions involved in fatigue, pain, emotional and reward processing, and the right ventral attention network in cognition. The axonal neuropathological mechanism(s) explaining increased axial diffusivity may account for the most prominent symptoms of Gulf War Illness.

METHODS: Gulf War veterans (n=31) and sedentary veteran and civilian controls (n=20) completed fMRI scans for diffusion tensor imaging. A combination of dolorimetry, subjective reports of pain and fatigue were correlated to white matter diffusivity properties to identify tracts associated with symptom constructs.

RESULTS: Gulf War Illness subjects had significantly correlated fatigue, pain, hyperalgesia, and increased axial diffusivity in the right inferior fronto-occipital fasciculus. ROC generated thresholds and subsequent binary regression analysis predicted CMI classification based upon axial diffusivity in the right inferior fronto-occipital fasciculus. These correlates were absent for controls in dichotomous regression analysis.

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