Randomized Trials of Percutaneous Microaxial Flow Pump Devices: JACC State-of-the-Art Review. [Review]

MedStar author(s):
Citation: Journal of the American College of Cardiology. 80(21):2028-2049, 2022 11 22.PMID: 36396205Institution: MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: Cardiovascular Disease Fellowship | Interventional Cardiology FellowshipForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Heart Failure | *Heart-Assist Devices | Heart Failure/th [Therapy] | Heart-Assist Devices/ae [Adverse Effects] | Hemodynamics | Humans | Randomized Controlled Trials as Topic | Shock, Cardiogenic/et [Etiology]Year: 2022Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007ISSN:
  • 0735-1097
Name of journal: Journal of the American College of CardiologyAbstract: The use of mechanical circulatory support devices in cardiovascular practice has risen exponentially over the past decade. These devices are currently used for hemodynamic support in patients with cardiogenic shock, high-risk percutaneous coronary intervention, left ventricular unloading, protection of kidneys, and right ventricular failure. The Impella (Abiomed) percutaneous microaxial flow pump devices are rapidly gaining popularity. However, despite their increasing use, there are limited randomized clinical trials (RCTs) to support the benefits of the therapy and growing concern regarding complication rates. Vascular problems, including bleeding and acute limb ischemia, are associated with the devices, but published reports also highlight risks for cardiac perforations, mitral chordae rupture, and stroke. In this review, we summarize the history, mechanism of action, previously published RCT data, and upcoming RCTs on these devices. Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.All authors: Ben-Dor I, Bernardo NL, Bhogal S, Hashim H, Johnson A, Kabir R, Pahuja M, Satler LF, Sheikh FH, Waksman R, Wermers JPFiscal year: FY2023Digital Object Identifier: Date added to catalog: 2022-12-13
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 36396205 Available 36396205

Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007

The use of mechanical circulatory support devices in cardiovascular practice has risen exponentially over the past decade. These devices are currently used for hemodynamic support in patients with cardiogenic shock, high-risk percutaneous coronary intervention, left ventricular unloading, protection of kidneys, and right ventricular failure. The Impella (Abiomed) percutaneous microaxial flow pump devices are rapidly gaining popularity. However, despite their increasing use, there are limited randomized clinical trials (RCTs) to support the benefits of the therapy and growing concern regarding complication rates. Vascular problems, including bleeding and acute limb ischemia, are associated with the devices, but published reports also highlight risks for cardiac perforations, mitral chordae rupture, and stroke. In this review, we summarize the history, mechanism of action, previously published RCT data, and upcoming RCTs on these devices. Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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