Sex-specific T-cell regulation of angiotensin II-dependent hypertension.

MedStar author(s):
Citation: Hypertension. 64(3):573-82, 2014 Sep.PMID: 24935938Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Comparative Study | Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Angiotensin II/ae [Adverse Effects] | *Hypertension/ci [Chemically Induced] | *Hypertension/pp [Physiopathology] | *T-Lymphocytes/pa [Pathology] | *T-Lymphocytes/ph [Physiology] | Adaptive Immunity/ph [Physiology] | Angiotensin II/pd [Pharmacology] | Animals | Blood Pressure/de [Drug Effects] | Blood Pressure/ph [Physiology] | Disease Models, Animal | Female | Heart Rate/de [Drug Effects] | Heart Rate/ph [Physiology] | Homeodomain Proteins/ge [Genetics] | Homeodomain Proteins/ph [Physiology] | Hypertension/pa [Pathology] | Interleukin-10/me [Metabolism] | Interleukin-17/me [Metabolism] | Male | Mice | Mice, Knockout | Sex Factors | Tumor Necrosis Factor-alpha/me [Metabolism]Year: 2014Local holdings: Available online from MWHC library: 1979 - presentISSN:
  • 0194-911X
Name of journal: HypertensionAbstract: Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice. Sex differences in peak mean arterial pressure in wild-type were lost in Rag1(-/-) mice (mm Hg: wild-type-F, 136+4.9 versus wild-type-M, 153+1.7; P<0.02; Rag1(-/-)-F, 135+2.1 versus Rag1(-/-)-M, 141+3.8). Peak mean arterial pressure was 13 mm Hg higher after adoptive transfer of male (CD3(M)->Rag1(-/-)-M) versus female (CD3(F)->Rag1(-/-)-M) T cells. CD3(M)->Rag1(-/-)-M mice exhibited higher splenic frequencies of proinflammatory interleukin-17A (2.4-fold) and tumor necrosis factor-alpha (2.2-fold)-producing T cells and lower plasma levels (13-fold) and renal mRNA expression (2.4-fold) of interleukin-10, whereas CD3(F)->Rag1(-/-)-M mice displayed a higher activation state in general and T-helper-1-biased renal inflammation. Greater T-cell infiltration into perivascular adipose tissue and kidney associated with increased pressor responses to angiotensin II if the T cell donor was male but not female and these sex differences in T-cell subset expansion and tissue infiltration were maintained for 7 to 8 weeks within the male host. Thus, the adaptive immune response and role of pro- and anti-inflammatory cytokine signaling in hypertension are distinct between the sexes and need to be understood to improve therapeutics for hypertension-associated disease in both men and women. 2014 American Heart Association, Inc.All authors: Dunn SE, Hay M, Ji H, Li X, Liu J, Sandberg K, Speth RC, Umans JG, Wu X, Zhang MA, Zheng WFiscal year: FY2015Digital Object Identifier: Date added to catalog: 2014-11-11
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 24935938 Available 24935938

Available online from MWHC library: 1979 - present

Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice. Sex differences in peak mean arterial pressure in wild-type were lost in Rag1(-/-) mice (mm Hg: wild-type-F, 136+4.9 versus wild-type-M, 153+1.7; P<0.02; Rag1(-/-)-F, 135+2.1 versus Rag1(-/-)-M, 141+3.8). Peak mean arterial pressure was 13 mm Hg higher after adoptive transfer of male (CD3(M)->Rag1(-/-)-M) versus female (CD3(F)->Rag1(-/-)-M) T cells. CD3(M)->Rag1(-/-)-M mice exhibited higher splenic frequencies of proinflammatory interleukin-17A (2.4-fold) and tumor necrosis factor-alpha (2.2-fold)-producing T cells and lower plasma levels (13-fold) and renal mRNA expression (2.4-fold) of interleukin-10, whereas CD3(F)->Rag1(-/-)-M mice displayed a higher activation state in general and T-helper-1-biased renal inflammation. Greater T-cell infiltration into perivascular adipose tissue and kidney associated with increased pressor responses to angiotensin II if the T cell donor was male but not female and these sex differences in T-cell subset expansion and tissue infiltration were maintained for 7 to 8 weeks within the male host. Thus, the adaptive immune response and role of pro- and anti-inflammatory cytokine signaling in hypertension are distinct between the sexes and need to be understood to improve therapeutics for hypertension-associated disease in both men and women. 2014 American Heart Association, Inc.

English

Powered by Koha