MedStar Authors catalog › Details for: Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease.
Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease. Journal: Journal of interventional cardiology. ISSN: 0896-4327. UI/PMID: 24517632. Subject(s): Aged | *Cholesterol, HDL/me [Metabolism] | Coronary Angiography/mt [Methods] | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/me [Metabolism] | Coronary Artery Disease/th [Therapy] | *Coronary Artery Disease | Female | Humans | Male | Middle Aged | *Percutaneous Coronary Intervention/mt [Methods] | Plaque, Atherosclerotic/pa [Pathology] | Plaque, Atherosclerotic/us [Ultrasonography] | *Plaque, Atherosclerotic | Predictive Value of Tests | Preoperative Care/mt [Methods] | Risk Assessment | Statistics as Topic | Ultrasonography, Interventional/mt [Methods] Institution(s): MedStar Heart & Vascular Institute | MedStar Health Research Institute Activity type: Journal Article. Medline article type(s): Journal Article | Randomized Controlled Trial Abbreviated citation: J. INTERVENT. CARDIOL.. 27(3):325-33, 2014 Jun. Abstract: OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease. Abstract: BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events. Abstract: METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40mg/dL, n=60) and a high HDL-C group (>40mg/dL, n=60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics. Abstract: RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r=0.03, P=0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P=0.02) and a greater percentage of attenuated plaque was found in this group (32.5+/-21.3% vs. 21.0+/-11.0%, P=0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30mg/dL, 41.9% in group with 30-39mg/dL, 36.4% in group with 40-59mg/dL, and 6.3% in group with >60mg/dL; P=0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions.
Abstract: CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.Copyright © 2014, Wiley Periodicals, Inc.