Cutaneous findings in hemophagocytic lymphohistiocytosis.
Citation: Dermatology. 230(3):234-43, 2015.PMID: 25677716Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleSubject headings: *Lymphohistiocytosis, Hemophagocytic/co [Complications] | *Skin Diseases/di [Diagnosis] | Adolescent | Adult | Child | Child, Preschool | Female | Humans | Infant | Infant, Newborn | Male | Middle Aged | Retrospective Studies | Skin Diseases/et [Etiology] | Young AdultYear: 2015ISSN:- 1018-8665
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 25677716 | Available | 25677716 |
BACKGROUND: Cutaneous findings associated with hemophagocytic lymphohistiocytosis (HLH) remain largely undescribed in the literature, yet are substantial and correlative with disease course.
CONCLUSION: Cutaneous eruptions as a consequence of HLH are variable in presentation and identified as a diagnosis of exclusion. Findings are both primarily and secondarily induced by altered immunity. Further study is needed to allow better understanding of the immunopathogenesis involved.
METHODS: We performed a retrospective chart review of patients meeting the criteria for HLH at two hospitals over 5 years. All patients meeting the criteria for HLH as defined by the HLH-2004 protocol were included.
OBJECTIVE: To catalog the clinical findings of cutaneous eruptions associated with HLH.
RESULTS: Cutaneous lesions were categorized based on clinical presentations and histology. Lesions independent of immunocompromised state were observed, including pyoderma gangrenosum, panniculitis, morbilliform eruptions, Stevens-Johnson syndrome, atypical targetoid lesions and bullae. Histologic findings were non-specific.
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