Cardiometabolic correlates of low type 2 diabetes incidence in western Alaska Native people - The WATCH study.

MedStar author(s):
Citation: Diabetes Research & Clinical Practice. 108(3):423-31, 2015 Jun.PMID: 25805711Institution: MedStar Health Research Institute | MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, American Recovery and Reinvestment Act | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Diabetes Mellitus, Type 2/eh [Ethnology] | *Indians, North American/eh [Ethnology] | *Metabolic Syndrome X/eh [Ethnology] | *Prediabetic State/eh [Ethnology] | Adult | Alaska/ep [Epidemiology] | Comorbidity | Female | Humans | Incidence | Male | Prediabetic State/co [Complications] | Prevalence | Risk FactorsYear: 2015ISSN:
  • 0168-8227
Name of journal: Diabetes research and clinical practiceAbstract: AIMS: Previously rare among Alaska Native (AN) people, type 2 diabetes (DM2) prevalence as indicated by registry data has increased by as much as 300% in some western Alaska regions. We sought to determine prevalence and incidence of DM2 and analyze associated cardiometabolic risk factors in western AN people.CONCLUSIONS: DM2 incidence in western AN people is substantially lower than that for U.S. whites; however, incidence of prediabetes is more than 10-fold higher than western AN DM2 incidence and more closely aligned with U.S. rates. Interventions aimed at achieving healthy lifestyles are needed to minimize risk factors and maximize protective factors for DM2 in this population.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.METHODS: DM2 and prediabetes prevalence and incidence were determined by the Western Alaska Tribal Collaborative for Health using consolidated data from cohort studies conducted during 2000-2010. Crude and age-adjusted incidence for DM2 and prediabetes were calculated using 2010 American Diabetes Association criteria. Effects of covariates on DM2 and prediabetes were determined using univariate and multivariate Cox proportional hazards analyses, adjusted for age and sex.RESULTS: Excluding baseline diabetes (n=124, 4.5%), 53 cases of new DM2 were identified among 2630 participants. Age- and sex-adjusted DM2 incidence was 4.3/1000 (95% CI 2.9, 5.0) person-years over an average 5.9-year follow up. After excluding baseline prediabetes, 387 new cases of prediabetes were identified among 1841 participants; adjusted prediabetes incidence was 44.5/1000 (95% CI 39.5, 49.5) person years. Independent predictors for DM2 included age, impaired fasting glucose, and metabolic syndrome; family history of diabetes and obesity were additional independent predictors for prediabetes.All authors: Austin MA, Boyer BB, Ebbesson SO, Hopkins SE, Howard BV, Jolly SE, Kaufmann C, Koller KR, Metzger JS, Raymer TW, Umans JG, Wilson ASFiscal year: FY2015Digital Object Identifier: Date added to catalog: 2016-06-13
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 25805711 Available 25805711

AIMS: Previously rare among Alaska Native (AN) people, type 2 diabetes (DM2) prevalence as indicated by registry data has increased by as much as 300% in some western Alaska regions. We sought to determine prevalence and incidence of DM2 and analyze associated cardiometabolic risk factors in western AN people.

CONCLUSIONS: DM2 incidence in western AN people is substantially lower than that for U.S. whites; however, incidence of prediabetes is more than 10-fold higher than western AN DM2 incidence and more closely aligned with U.S. rates. Interventions aimed at achieving healthy lifestyles are needed to minimize risk factors and maximize protective factors for DM2 in this population.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

METHODS: DM2 and prediabetes prevalence and incidence were determined by the Western Alaska Tribal Collaborative for Health using consolidated data from cohort studies conducted during 2000-2010. Crude and age-adjusted incidence for DM2 and prediabetes were calculated using 2010 American Diabetes Association criteria. Effects of covariates on DM2 and prediabetes were determined using univariate and multivariate Cox proportional hazards analyses, adjusted for age and sex.

RESULTS: Excluding baseline diabetes (n=124, 4.5%), 53 cases of new DM2 were identified among 2630 participants. Age- and sex-adjusted DM2 incidence was 4.3/1000 (95% CI 2.9, 5.0) person-years over an average 5.9-year follow up. After excluding baseline prediabetes, 387 new cases of prediabetes were identified among 1841 participants; adjusted prediabetes incidence was 44.5/1000 (95% CI 39.5, 49.5) person years. Independent predictors for DM2 included age, impaired fasting glucose, and metabolic syndrome; family history of diabetes and obesity were additional independent predictors for prediabetes.

English

Powered by Koha