Embolic Protection Devices in Transcatheter Aortic Valve Replacement. [Review]

MedStar author(s):
Citation: Circulation: Cardiovascular Interventions. 9(3):e003284, 2016 MarPMID: 26951618Institution: MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: NeurologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Aortic Valve | *Cardiac Catheterization/is [Instrumentation] | *Cerebrovascular Disorders/pc [Prevention & Control] | *Embolic Protection Devices | *Heart Valve Diseases/th [Therapy] | *Heart Valve Prosthesis | *Heart Valve Prosthesis Implantation/is [Instrumentation] | Aortic Valve/pp [Physiopathology] | Cardiac Catheterization/ae [Adverse Effects] | Cerebrovascular Disorders/di [Diagnosis] | Cerebrovascular Disorders/et [Etiology] | Heart Valve Diseases/di [Diagnosis] | Heart Valve Diseases/pp [Physiopathology] | Heart Valve Prosthesis Implantation/ae [Adverse Effects] | Humans | Prosthesis Design | Risk Assessment | Risk Factors | Treatment OutcomeYear: 2016Local holdings: Available online from MWHC library: 2008 - presentISSN:
  • 1941-7640
Name of journal: Circulation. Cardiovascular interventionsAbstract: Copyright © 2016 American Heart Association, Inc.The initially reported periprocedural neurological events rates associated with transcatheter aortic valve replacement raised concerns that ultimately led to the development and to the clinical research of novel embolic protection devices. Although the reduction of clinical stroke is a desired goal, the current research design of embolic protection devices focuses on surrogate markers of the clinical disease, primarily on silent central nervous system lesions observed in postprocedural diffuse-weighted magnetic resonance imaging and cognitive function testing. As the mere presence of particulate debris in brain matter may not correlate with the extent of brain injury, cognitive function, or quality of life, the clinical significance of embolic protection devices has yet to be determined, and interpretation of study results with regard to real-life clinical use should be viewed accordingly. The purpose of this article is to provide an overview of the updated ongoing clinical research on embolic protection devices and present its major caveats. All authors: Benson RT, Steinvil A, Waksman RFiscal year: FY2016Digital Object Identifier: Date added to catalog: 2017-03-08
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 26951618 Available 26951618

Available online from MWHC library: 2008 - present

Copyright © 2016 American Heart Association, Inc.

The initially reported periprocedural neurological events rates associated with transcatheter aortic valve replacement raised concerns that ultimately led to the development and to the clinical research of novel embolic protection devices. Although the reduction of clinical stroke is a desired goal, the current research design of embolic protection devices focuses on surrogate markers of the clinical disease, primarily on silent central nervous system lesions observed in postprocedural diffuse-weighted magnetic resonance imaging and cognitive function testing. As the mere presence of particulate debris in brain matter may not correlate with the extent of brain injury, cognitive function, or quality of life, the clinical significance of embolic protection devices has yet to be determined, and interpretation of study results with regard to real-life clinical use should be viewed accordingly. The purpose of this article is to provide an overview of the updated ongoing clinical research on embolic protection devices and present its major caveats.

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