Intestinal Transplant Inflammation: the Third Inflammatory Bowel Disease. [Review]

MedStar author(s):
Citation: Current Gastroenterology Reports. 18(11):56, 2016 NovPMID: 27645751Institution: MedStar Washington Hospital CenterDepartment: Surgery/TransplantationForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Inflammatory Bowel Diseases/et [Etiology] | *Intestines/tr [Transplantation] | Graft Rejection/im [Immunology] | Humans | Immunity, Mucosal | Inflammatory Bowel Diseases/im [Immunology] | Intestinal Mucosa/im [Immunology] | Nod2 Signaling Adaptor Protein/im [Immunology] | T-Lymphocyte Subsets/im [Immunology] | Th17 Cells/im [Immunology]Year: 2016ISSN:
  • 1522-8037
Name of journal: Current gastroenterology reportsAbstract: Intestinal transplantation is the most immunologically complex of all abdominal organ transplants. Understanding the role both humoral and innate and adaptive cellular immunity play in intestinal transplantation is critical to improving outcomes and increasing indications for patients suffering from intestinal failure. Recent findings highlighting the impact of donor-specific antibodies on intestinal allografts, the role of NOD2 as a key regulator of intestinal immunity, the protective effects of innate lymphoid cells, and the role of Th17 in acute cellular rejection are reviewed here.All authors: Cosentino C, Fishbein TM, Kaiser J, Kroemer A, Matsumoto CSFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-03-17
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Journal Article MedStar Authors Catalog Article 27645751 Available 27645751

Intestinal transplantation is the most immunologically complex of all abdominal organ transplants. Understanding the role both humoral and innate and adaptive cellular immunity play in intestinal transplantation is critical to improving outcomes and increasing indications for patients suffering from intestinal failure. Recent findings highlighting the impact of donor-specific antibodies on intestinal allografts, the role of NOD2 as a key regulator of intestinal immunity, the protective effects of innate lymphoid cells, and the role of Th17 in acute cellular rejection are reviewed here.

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