Malignant Glomus Tumor Arising in a Long Standing Precursor Lesion.

MedStar author(s):
Citation: American Journal of Dermatopathology. 38(5):384-7, 2016 MayPMID: 26760685Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Case Reports | Journal ArticleSubject headings: *Cell Transformation, Neoplastic | *Glomus Tumor/pa [Pathology] | *Skin Neoplasms/pa [Pathology] | Aged, 80 and over | Biomarkers, Tumor/an [Analysis] | Biopsy | Cell Proliferation | Female | Glomus Tumor/ch [Chemistry] | Glomus Tumor/su [Surgery] | Humans | Immunohistochemistry | Skin Neoplasms/ch [Chemistry] | Skin Neoplasms/su [Surgery] | Time Factors | Treatment Outcome | Tumor BurdenYear: 2016Local holdings: Available online from MWHC library: Feb 1996 - presentISSN:
  • 0193-1091
Name of journal: The American Journal of dermatopathologyAbstract: Malignant glomus tumor is an exceedingly rare vascular malignancy of unclear etiology, which is believed to arise de novo or from malignant transformation of a benign glomus tumor. The authors present a case of an elderly woman evaluated for a painful 2.5-cm purple-brown tumor on the right forearm that grew rapidly within a long-standing, seemingly benign lesion. An excisional biopsy revealed a multilobular dermal tumor composed of areas of benign-appearing glomus tumor cells interspersed with areas of dense, pleomorphic cells arranged in sheets and fascicles with an elevated mitotic rate. The diagnosis of malignant glomus tumor was made on the basis of the lesion's nuclear atypia and elevated mitotic rate. This case demonstrates malignant transformation of a presumably benign glomus tumor precursor lesion highlighting this rarely reported phenomenon. The authors present this case to raise awareness of this vascular malignancy that carries a significant risk of metastasis.All authors: Anatelli F, Damavandy AA, Skelsey MKFiscal year: FY2016Digital Object Identifier: Date added to catalog: 2017-03-17
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Journal Article MedStar Authors Catalog Article 26760685 Available 26760685

Available online from MWHC library: Feb 1996 - present

Malignant glomus tumor is an exceedingly rare vascular malignancy of unclear etiology, which is believed to arise de novo or from malignant transformation of a benign glomus tumor. The authors present a case of an elderly woman evaluated for a painful 2.5-cm purple-brown tumor on the right forearm that grew rapidly within a long-standing, seemingly benign lesion. An excisional biopsy revealed a multilobular dermal tumor composed of areas of benign-appearing glomus tumor cells interspersed with areas of dense, pleomorphic cells arranged in sheets and fascicles with an elevated mitotic rate. The diagnosis of malignant glomus tumor was made on the basis of the lesion's nuclear atypia and elevated mitotic rate. This case demonstrates malignant transformation of a presumably benign glomus tumor precursor lesion highlighting this rarely reported phenomenon. The authors present this case to raise awareness of this vascular malignancy that carries a significant risk of metastasis.

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