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Lower skin cancer risk in women with higher body mass index: the women's health initiative observational study.

by Aroda, Vanita R.
Citation: Cancer Epidemiology, Biomarkers & Prevention. 22(12):2412-5, 2013 Dec..Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.ISSN: 1055-9965.Full author list: Tang JY; Henderson MT; Hernandez-Boussard T; Kubo J; Desai M; Sims ST; Aroda V; Thomas F; McTiernan A; Stefanick ML.UI/PMID: 24042260.Subject(s): Age Factors | Aged | *Body Mass Index | Cohort Studies | Female | Humans | Logistic Models | *Melanoma/ep [Epidemiology] | Middle Aged | Obesity/ep [Epidemiology] | Risk Factors | *Skin Neoplasms/ep [Epidemiology] | United States/ep [Epidemiology] | Women's HealthInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralDigital Object Identifier: (Click here) Abbreviated citation: Cancer Epidemiol Biomarkers Prev. 22(12):2412-5, 2013 Dec.Local Holdings: Available online from MWHC library: Nov 1991 - present (after 1 year).Abstract: The unclear relationship of obesity to incident melanoma and nonmelanoma skin cancer (NMSC) risks was evaluated in the large, geographically diverse longitudinal, prospective Women's Health Initiative (WHI) observational study. Risks of melanoma and NMSC in normal weight women were compared with risks in overweight [body mass index (BMI) = 25-29.0 kg/m(2)] and obese (BMI > 30 kg/m(2)) women, using Cox proportional hazards models for melanoma and logistic regression for NMSC. Over a mean 9.4 years of follow-up, there were 386 melanoma and 9,870 NSMC cases. Risk of melanoma did not differ across weight categories (P = 0.86), whereas in fully adjusted models, NMSC risk was lower in overweight [OR, 0.93; 95% confidence interval (CI), 0.89-0.99] and obese (OR, 0.85; 95% CI, 0.80-0.91) women (P < 0.001). Excess body weight was not associated with melanoma risk in postmenopausal women but was inversely associated with NMSC risk, possibly due to lower sun exposure in overweight and obese women. This supports previous work demonstrating the relationship between excess body weight and skin cancer risk. 2013 AACR.

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