The possible role of glutathione-S-transferase activity in diabetic nephropathy. [Review]
Citation: International Journal of Immunopathology & Pharmacology. 28(1):129-33, 2015 MarPMID: 25816416Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Letter | ReviewSubject headings: *Diabetes Complications/me [Metabolism] | *Diabetic Nephropathies/me [Metabolism] | *Glutathione Transferase/me [Metabolism] | Biomarkers/me [Metabolism] | Humans | Kidney Failure, Chronic/me [Metabolism] | Renal Insufficiency, Chronic/me [Metabolism]Year: 2015ISSN:- 0394-6320
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 25816416 | Available | 25816416 |
Copyright © The Author(s) 2015.
The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.
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