The possible role of glutathione-S-transferase activity in diabetic nephropathy. [Review]

MedStar author(s):
Citation: International Journal of Immunopathology & Pharmacology. 28(1):129-33, 2015 MarPMID: 25816416Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Letter | ReviewSubject headings: *Diabetes Complications/me [Metabolism] | *Diabetic Nephropathies/me [Metabolism] | *Glutathione Transferase/me [Metabolism] | Biomarkers/me [Metabolism] | Humans | Kidney Failure, Chronic/me [Metabolism] | Renal Insufficiency, Chronic/me [Metabolism]Year: 2015ISSN:
  • 0394-6320
Name of journal: International journal of immunopathology and pharmacologyAbstract: Copyright © The Author(s) 2015.The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication. All authors: Campia U, Cardillo C, Costa A, Di Cola G, Di Daniele N, Lauro D, Marrone G, Nistico S, Noce A, Rovella V, Tarantino A, Tesauro MFiscal year: FY2015Digital Object Identifier: Date added to catalog: 2017-05-06
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Journal Article MedStar Authors Catalog Article 25816416 Available 25816416

Copyright © The Author(s) 2015.

The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.

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