MedStar Authors catalog › Details for: Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program.
Citation: Diabetes Care. 37(10):2738-45, 2014 Oct..Journal: Diabetes care.ISSN: 0149-5992.Full author list: Delahanty LM; Pan Q; Jablonski KA; Aroda VR; Watson KE; Bray GA; Kahn SE; Florez JC; Perreault L; Franks PW; Diabetes Prevention Program Research Group.UI/PMID: 25024396.Subject(s): Adult | Blood Glucose/me [Metabolism] | Body Weight/ph [Physiology] | Cardiovascular Diseases/ep [Epidemiology] | *Cardiovascular Diseases/et [Etiology] | *Diabetes Mellitus/ep [Epidemiology] | *Diabetes Mellitus/et [Etiology] | Diabetes Mellitus/pc [Prevention & Control] | Female | Humans | Incidence | Life Style | Male | Metabolic Diseases/ep [Epidemiology] | *Metabolic Diseases/et [Etiology] | Middle Aged | Prospective Studies | Risk Factors | *Weight Loss/ph [Physiology] | Weight Reduction ProgramsInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Observational Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.2337/dc14-0018 (Click here)Abbreviated citation: Diabetes Care. 37(10):2738-45, 2014 Oct.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: OBJECTIVE: This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors.Abstract: RESEARCH DESIGN AND METHODS: This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm (n = 1,000) for predictors of incident diabetes and improvement in cardiometabolic risk factors over 2 years.Abstract: RESULTS: Although weight loss in the first 6 months was protective of diabetes (hazard ratio [HR] 0.94 per kg, 95% CI 0.90, 0.98; P < 0.01) and cardiometabolic risk factors (P < 0.01), weight loss from 0 to 2 years was the strongest predictor of reduced diabetes incidence (HR 0.90 per kg, 95% CI 0.87, 0.93; P < 0.01) and cardiometabolic risk factor improvement (e.g., fasting glucose: beta = -0.57 mg/dL per kg, 95% CI -0.66, -0.48; P < 0.01). Weight cycling (defined as number of 5-lb [2.25-kg] weight cycles) ranged 0-6 times per participant and was positively associated with incident diabetes (HR 1.33, 95% CI 1.12, 1.58; P < 0.01), fasting glucose (beta = 0.91 mg/dL per cycle; P = 0.02), HOMA-IR (beta = 0.25 units per cycle; P = 0.04), and systolic blood pressure (beta = 0.94 mmHg per cycle; P = 0.01). After adjustment for baseline weight, the effect of weight cycling remained statistically significant for diabetes risk (HR 1.22, 95% CI 1.02, 1.47; P = 0.03) but not for cardiometabolic traits.Abstract: CONCLUSIONS: Two-year weight loss was the strongest predictor of reduced diabetes risk and improvements in cardiometabolic traits.Copyright � 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.