Association between Dietary Energy Density and Incident Type 2 Diabetes in the Women's Health Initiative.
Citation: Journal of the Academy of Nutrition & Dietetics. 117(5):778-785.e1, 2017 MayPMID: 28065634Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Diabetes Mellitus, Type 2/ep [Epidemiology] | *Diet | *Energy Intake | *Women's Health | Aged | Body Mass Index | Female | Humans | Middle Aged | Nutrition Assessment | Postmenopause | Prospective Studies | Risk Factors | Surveys and Questionnaires | United States | Waist CircumferenceYear: 2017Abstract: BACKGROUND: Dietary energy density, or energy available in relation to gram intake, can inform disease risk.CONCLUSIONS: In this prospective study, a higher baseline dietary energy density was associated with higher incidence of type 2 diabetes among postmenopausal women, both overall, and in women with elevated waist circumference. Copyright © 2017 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.DESIGN: Dietary energy density, weight status, and type 2 diabetes incidence were prospectively characterized in a large cohort of postmenopausal women participating in one or more clinical trials or an observational study.MAIN OUTCOME MEASURES: The primary outcome was incident type 2 diabetes.OBJECTIVE: The objective of this study was to investigate the association between baseline dietary energy density and risk of incident type 2 diabetes in postmenopausal women.PARTICIPANTS/SETTING: The study involved 161,808 postmenopausal women recruited to the Women's Health Initiative observational study or clinical trials at 40 centers across the United States between 1993 and 1998.RESULTS: A total of 143,204 participants without self-reported diabetes at enrollment completed baseline dietary assessment and were followed for 12.7+/-4.6 years. Risk of diabetes developing was 24% greater for women in the highest dietary energy density quintile compared with the lowest after adjusting for confounders (95% CI 1.17 to 1.32). Body mass index (calculated as kg/m<sup>2</sup>) and waist circumference mediated the relationship between dietary energy density and diabetes. In waist circumference-stratified analysis, women in dietary energy density quintiles 2 to 5 with waist circumferences >88 cm were at 9% to 12% greater risk of diabetes developing compared with women with waist circumference <=88 cm.STATISTICAL ANALYSES PERFORMED: The association between dietary energy density quintiles and incident diabetes was tested using Cox proportional hazards regression.Fiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-07-18| Item type | Current library | Collection | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | 28065634 | Available | 28065634 |
BACKGROUND: Dietary energy density, or energy available in relation to gram intake, can inform disease risk.
CONCLUSIONS: In this prospective study, a higher baseline dietary energy density was associated with higher incidence of type 2 diabetes among postmenopausal women, both overall, and in women with elevated waist circumference. Copyright © 2017 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
DESIGN: Dietary energy density, weight status, and type 2 diabetes incidence were prospectively characterized in a large cohort of postmenopausal women participating in one or more clinical trials or an observational study.
MAIN OUTCOME MEASURES: The primary outcome was incident type 2 diabetes.
OBJECTIVE: The objective of this study was to investigate the association between baseline dietary energy density and risk of incident type 2 diabetes in postmenopausal women.
PARTICIPANTS/SETTING: The study involved 161,808 postmenopausal women recruited to the Women's Health Initiative observational study or clinical trials at 40 centers across the United States between 1993 and 1998.
RESULTS: A total of 143,204 participants without self-reported diabetes at enrollment completed baseline dietary assessment and were followed for 12.7+/-4.6 years. Risk of diabetes developing was 24% greater for women in the highest dietary energy density quintile compared with the lowest after adjusting for confounders (95% CI 1.17 to 1.32). Body mass index (calculated as kg/m<sup>2</sup>) and waist circumference mediated the relationship between dietary energy density and diabetes. In waist circumference-stratified analysis, women in dietary energy density quintiles 2 to 5 with waist circumferences >88 cm were at 9% to 12% greater risk of diabetes developing compared with women with waist circumference <=88 cm.
STATISTICAL ANALYSES PERFORMED: The association between dietary energy density quintiles and incident diabetes was tested using Cox proportional hazards regression.
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