Combining Dopaminergic Facilitation with Robot-Assisted Upper Limb Therapy in Stroke Survivors: A Focused Review.

MedStar author(s):
Citation: American Journal of Physical Medicine & Rehabilitation. 95(6):459-74, 2016 JunPMID: 26829074Institution: MedStar Washington Hospital CenterDepartment: Medicine/General Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Dopamine Agents/tu [Therapeutic Use] | *Exercise Therapy/mt [Methods] | *Hemiplegia/rh [Rehabilitation] | *Robotics/mt [Methods] | *Stroke Rehabilitation/mt [Methods] | Combined Modality Therapy | Hemiplegia/dt [Drug Therapy] | Hemiplegia/pp [Physiopathology] | Humans | Levodopa/tu [Therapeutic Use] | Neuronal Plasticity/de [Drug Effects] | Stroke/co [Complications] | Stroke/dt [Drug Therapy] | Stroke/pp [Physiopathology] | Survivors | Upper Extremity/pp [Physiopathology]Year: 2016Local holdings: Available online from MWHC library: 1996 - presentISSN:
  • 0894-9115
Name of journal: American journal of physical medicine & rehabilitationAbstract: Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. The aim of this article is to critically review the rationale behind targeting multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality-based reward learning to alleviate upper extremity impairment in stroke survivors. Methods for personalizing pharmacologic facilitation to each individual's unique biology are also reviewed. At the molecular level, treatment with levodopa was shown to induce long-term potentiation-like and practice-dependent plasticity. Clinically, trials combining conventional therapy with levodopa in stroke survivors yielded statistically significant but clinically unconvincing outcomes because of limited personalization, standardization, and reproducibility. Robotic therapy can induce neuroplasticity by delivering intensive, reproducible, and functionally meaningful interventions that are objective enough for the rigors of research. Robotic therapy also provides an apt platform for virtual reality, which boosts learning by engaging reward circuits. The future of stroke rehabilitation should target distinct molecular, synaptic, and cortical sites through personalized multimodal treatments to maximize motor recovery.All authors: Bonato P, Daneault JF, Fregni F, Gallegos JG, Pajaro-Blazquez M, Pons J, Tran DA, Zafonte RFiscal year: FY2016Digital Object Identifier: Date added to catalog: 2017-05-24
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 26829074 Available 26829074

Available online from MWHC library: 1996 - present

Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. The aim of this article is to critically review the rationale behind targeting multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality-based reward learning to alleviate upper extremity impairment in stroke survivors. Methods for personalizing pharmacologic facilitation to each individual's unique biology are also reviewed. At the molecular level, treatment with levodopa was shown to induce long-term potentiation-like and practice-dependent plasticity. Clinically, trials combining conventional therapy with levodopa in stroke survivors yielded statistically significant but clinically unconvincing outcomes because of limited personalization, standardization, and reproducibility. Robotic therapy can induce neuroplasticity by delivering intensive, reproducible, and functionally meaningful interventions that are objective enough for the rigors of research. Robotic therapy also provides an apt platform for virtual reality, which boosts learning by engaging reward circuits. The future of stroke rehabilitation should target distinct molecular, synaptic, and cortical sites through personalized multimodal treatments to maximize motor recovery.

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