Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study.

MedStar author(s):
Citation: PLoS ONE [Electronic Resource]. 11(7):e0159548, 2016PMID: 27434237Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Indians, North American | *Metabolome | *Obesity/bl [Blood] | *Obesity/eh [Ethnology] | Adolescent | Adult | Amino Acids/bl [Blood] | Blood Glucose/me [Metabolism] | Body Mass Index | Chromatography, Liquid | Databases, Factual | Fasting | Female | Humans | Insulin Resistance | Male | Mass Spectrometry | Metabolomics/mt [Methods] | Middle Aged | Obesity/di [Diagnosis] | Obesity/pp [Physiopathology] | Peptides/bl [Blood] | Prospective Studies | Risk Factors | Sphingolipids/bl [Blood] | Steroids/bl [Blood] | United States | Waist CircumferenceYear: 2016Local holdings: Available online through MWHC library: 2006 - presentISSN:
  • 1932-6203
Name of journal: PloS oneAbstract: Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.All authors: Best LG, Howard BV, Jones DP, Lee ET, Tran VT, Umans JG, Uppal K, Zhao J, Zhao Q, Zhu YFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-05-08
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 27434237 Available 27434237

Available online through MWHC library: 2006 - present

Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.

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