MedStar Authors catalog › Details for: Impact of Functional Versus Organic Baseline Mitral Regurgitation on Short- and Long-Term Outcomes After Transcatheter Aortic Valve Replacement.
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Impact of Functional Versus Organic Baseline Mitral Regurgitation on Short- and Long-Term Outcomes After Transcatheter Aortic Valve Replacement.

by Kiramijyan, Starkis; Koifman, Edward; Asch, Federico M; Magalhaes, Marco A; Didier, Romain; Escarcega, Ricardo O; Negi, Smita I; Baker, Nevin C; Jerusalem, Zachary D; Gai, Jiaxiang; Torguson, Rebecca; Okubagzi, Petros; Wang, Zuyue; Shults, Christian; Ben-Dor, Itsik; Corso, Paul J; Satler, Lowell F; Pichard, Augusto D; Waksman, Ron.
Citation: American Journal of Cardiology. 117(5):839-46, 2016 Mar 1..Journal: The American journal of cardiology.Published: 2016ISSN: 0002-9149.Full author list: Kiramijyan S; Koifman E; Asch FM; Magalhaes MA; Didier R; Escarcega RO; Negi SI; Baker NC; Jerusalem ZD; Gai J; Torguson R; Okubagzi P; Wang Z; Shults CC; Ben-Dor I; Corso PJ; Satler LF; Pichard AD; Waksman R.UI/PMID: 26873331.Subject(s): Aged, 80 and over | Aortic Valve Stenosis/di [Diagnosis] | Aortic Valve Stenosis/mo [Mortality] | *Aortic Valve Stenosis/su [Surgery] | District of Columbia/ep [Epidemiology] | Echocardiography | Female | Follow-Up Studies | Humans | Male | Mitral Valve Insufficiency/et [Etiology] | Mitral Valve Insufficiency/mo [Mortality] | *Mitral Valve Insufficiency/pp [Physiopathology] | *Postoperative Complications | Prognosis | Retrospective Studies | Severity of Illness Index | Survival Rate/td [Trends] | Time Factors | *Transcatheter Aortic Valve Replacement/ae [Adverse Effects] | Treatment Outcome | *Ventricular Function, Left/ph [Physiology] | *Ventricular Remodeling/ph [Physiology]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1016/j.amjcard.2015.11.064 (Click here) Abbreviated citation: Am J Cardiol. 117(5):839-46, 2016 Mar 1.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: The impact of the specific etiology of mitral regurgitation (MR) on outcomes in the transcatheter aortic valve replacement (TAVR) population is unknown. This study aimed to evaluate the longitudinal changes in functional versus organic MR after TAVR in addition to their impact on survival. Consecutive patients who underwent TAVR from May 2007 to May 2015 who had baseline significant (moderate or greater) MR were included. Transthoracic echocardiography was used to evaluate the cohort at baseline, post-procedure, 30-day, 6-month, and 1-year follow-up. The primary outcomes included mortality at 30 days and 1 year. Longitudinal, mixed-model regression analyses were performed to assess the differences in the magnitude of longitudinal changes of MR, left ventricular (LV) ejection fraction, and New York Heart Association functional class. Seventy patients (44% men, mean 83 years) with moderate or greater MR at baseline (30 functional vs 40 organic) were included, with the functional group having a statistically significant mean younger age and higher rates of previous coronary artery bypass grafting. Kaplan-Meier cumulative mortality rates were similar: 30 days (10% vs 17.5%, unadjusted log-ranked p = 0.413) and 1 year (29.4% vs 23.2%, unadjusted log-ranked p = 0.746) in the functional versus organic MR groups, respectively. There were greater degrees of short- and long-term improvement in MR severity (slope difference p = 0.0008), LV ejection fraction (slope difference p = 0.0009), and New York Heart Association class (slope difference p = 0.0054) in the functional versus organic group. In conclusion, patients with significant functional versus organic MR who underwent TAVR have similar short- and long-term survival; nevertheless, those with a functional origin are more likely to have significant improvements in MR severity, LV-positive remodeling, and functional class. These findings may help strategize therapies for MR in patients with combined aortic and mitral valve disease who are undergoing TAVR.Copyright © 2016 Elsevier Inc. All rights reserved.

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