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Mucinous Cystadenoma in Children and Adolescents.

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Citation: Journal of Pediatric & Adolescent Gynecology. 30(4):495-498, 2017 AugPMID: 28216128Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology/Pediatric and AdolescentForm of publication: Journal ArticleMedline article type(s): Journal ArticleYear: 2017 Local holdings: Available online through MWHC library: 2002 - presentMH - AdolescentMH - ChildMH - *Chromogranins/ge [Genetics]MH - Cystadenoma, Mucinous/ge [Genetics]MH - *Cystadenoma, Mucinous/pa [Pathology]MH - Cystadenoma, Mucinous/th [Therapy]MH - Databases, FactualMH - FemaleMH - *GTP-Binding Protein alpha Subunits, Gs/ge [Genetics]MH - HumansMH - MutationMH - Neoplasm Recurrence, Local/su [Surgery]MH - Ovarian Neoplasms/su [Surgery]MH - OvariectomyISSN:

1083-3188

Name of journal: Journal of pediatric and adolescent gynecologyAbstract: CONCLUSION: This series supports the use of ovary-sparing surgery in the treatment of MCA. Further research exploring possible genetic variants such as the GNAS gene in children and adolescents diagnosed with MCA is warranted.Copyright (c) 2017. Published by Elsevier Inc.DESIGN: and Participants: After Institutional Board Review approval, the pathology database of a large urban children's hospital was queried to identify adolescents with MCA between the years 2008 and 2014. 14 patients, aged 8-18 years (median 14), were identified. A buccal swab for genetic testing was obtained from a subset of consenting patients.MAIN OUTCOME MEASURES: MCA recurrence; ovarian return to normal size; GNAS gene variants.RESULTS: Two patients underwent oophorectomies, while the remaining 12 underwent cystectomies. Follow-up ultrasound revealed slow return of ovary to normal size. Of the 10 patients with available follow-up data, there were no recurrences at a median of 225 days from surgery. Four patients consented to a buccal swab for genetic testing, and the GNAS gene was noted to have rare variants in 2 patients.STUDY OBJECTIVE: Mucinous cystadenomas (MCAs) are benign epithelial ovarian tumors that occur rarely in children and adolescents. As children and adolescents typically have their childbearing years ahead of them, conservative therapy is indicated. However, there is concern that ovarian cystectomy may be associated with significant recurrence risk in MCA. Furthermore, GNAS gene mutations are associated with McCune-Albright Syndrome, which is associated with cystic ovaries. We sought to evaluate the outcomes of children and adolescents with MCA treated conservatively. A subset of patients underwent GNAS gene testing.All authors: Cowan RA, Faucz FR, Gomez-Lobo V, Haber EN, Stratakis CAFiscal year: FY2017Digital Object Identifier:

https://dx.doi.org/10.1016/j.jpag.2017.02.001

Date added to catalog: 2017-05-06

Holdings ( 1 )
Title notes ( 8 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	28216128	Available		28216128

Available online through MWHC library: 2002 - presentMH - AdolescentMH - ChildMH - *Chromogranins/ge [Genetics]MH - Cystadenoma, Mucinous/ge [Genetics]MH - *Cystadenoma, Mucinous/pa [Pathology]MH - Cystadenoma, Mucinous/th [Therapy]MH - Databases, FactualMH - FemaleMH - *GTP-Binding Protein alpha Subunits, Gs/ge [Genetics]MH - HumansMH - MutationMH - Neoplasm Recurrence, Local/su [Surgery]MH - Ovarian Neoplasms/su [Surgery]MH - Ovariectomy

CONCLUSION: This series supports the use of ovary-sparing surgery in the treatment of MCA. Further research exploring possible genetic variants such as the GNAS gene in children and adolescents diagnosed with MCA is warranted.

DESIGN: and Participants: After Institutional Board Review approval, the pathology database of a large urban children's hospital was queried to identify adolescents with MCA between the years 2008 and 2014. 14 patients, aged 8-18 years (median 14), were identified. A buccal swab for genetic testing was obtained from a subset of consenting patients.

MAIN OUTCOME MEASURES: MCA recurrence; ovarian return to normal size; GNAS gene variants.

RESULTS: Two patients underwent oophorectomies, while the remaining 12 underwent cystectomies. Follow-up ultrasound revealed slow return of ovary to normal size. Of the 10 patients with available follow-up data, there were no recurrences at a median of 225 days from surgery. Four patients consented to a buccal swab for genetic testing, and the GNAS gene was noted to have rare variants in 2 patients.

STUDY OBJECTIVE: Mucinous cystadenomas (MCAs) are benign epithelial ovarian tumors that occur rarely in children and adolescents. As children and adolescents typically have their childbearing years ahead of them, conservative therapy is indicated. However, there is concern that ovarian cystectomy may be associated with significant recurrence risk in MCA. Furthermore, GNAS gene mutations are associated with McCune-Albright Syndrome, which is associated with cystic ovaries. We sought to evaluate the outcomes of children and adolescents with MCA treated conservatively. A subset of patients underwent GNAS gene testing.

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