Association of body mass index and waist circumference with subclinical atherosclerosis in retired NFL players.Published: Southern medical journal ; 2014Edition: Southern Medical Journal. 107(10):633-9, 2014 Oct.ISSN: 0038-4348.UI/PMID: 25279867.Subject(s): Atherosclerosis/di [Diagnosis] | *Atherosclerosis/et [Etiology] | Atherosclerosis/me [Metabolism] | Biomarkers/me [Metabolism] | *Body Mass Index | Calcium/me [Metabolism] | Cohort Studies | Coronary Vessels/me [Metabolism] | *Football | Humans | Logistic Models | Male | Metabolic Syndrome X/co [Complications] | Middle Aged | *Retirement | Risk Factors | *Waist CircumferenceInstitution(s): MedStar Health Research Institute | MedStar Union Memorial HospitalDepartment(s): MedStar Sports Medicine Research Center | Orthopaedics | MedStar Sports MedicineActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.SOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.14423/SMJ.0000000000000173 (Click here)
Abbreviated citation:Local Holdings: Available online through MWHC library: 2003 - present, Available in print through MWHC library: 1999 - 2006.Abstract: OBJECTIVES: It is unknown which measure of adiposity (body mass index [BMI] or waist circumference [WC]) is associated with subclinical atherosclerosis in retired National Football League (NFL) players and whether this relation is attenuated after adjusting for components of the metabolic syndrome (elevated triglycerides, fasting glucose, and low levels of high-density lipoprotein-cholesterol [HDL-C]) that frequently coexist with obesity; METHODS: Coronary artery calcium (CAC) was measured in 926 retired NFL players. BMI was calculated as weight (in kilograms)/height (in meters)(2) and WC was measured in inches. Logistic regression analyses adjusting for age, race, systolic blood pressure, high sensitivity C-reactive protein, triglycerides, HDL-C, and fasting blood glucose were performed to evaluate whether BMI or WC was independently associated with the presence of CAC (CAC score >0); RESULTS: The median age, BMI and WC were 54 years, 31 kg/m(2), and 40 inches, respectively. CAC was present in 61% (n = 562) of retired players. Adjusting for age, race, systolic blood pressure, high sensitivity C-reactive protein, triglycerides, HDL-C, and fasting blood glucose, each standard deviation increase in BMI (4.85 kg/m(2)) was significantly associated with CAC (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.03-1.50), but each standard deviation increase in WC (10.53 inches) was not significantly associated with CAC (OR 1.18, 95% CI 0.96-1.45). There was a significant association for the presence of CAC for highest versus lowest quartiles of both BMI (OR 1.93, 95% CI 1.13-3.28) and WC (OR 1.75, 95% CI 1.05-2.92), although the trend for the presence of CAC was significant only across increasing BMI quartiles, even in models that included WC; CONCLUSIONS: In retired NFL players both BMI and WC were associated with CAC. Higher BMI may be associated with an increasing trend for the presence of CAC independent of WC.
South Med J. 107(10):633-9, 2014 Oct.