MedStar Authors catalog › Details for: Rhinotopic therapy for refractory chronic rhinosinusitis: a study of 20 cases.
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Rhinotopic therapy for refractory chronic rhinosinusitis: a study of 20 cases.

by Shikani, Alan H.
Published: Ear, nose, & throat journal ; 2014Edition: Ear, Nose, & Throat Journal. 93(4-5):E48-54, 2014 Apr-May.ISSN: 0145-5613.UI/PMID: 24817242.Subject(s): Adrenal Cortex Hormones/ad [Administration & Dosage] | Adult | Aged | Anti-Bacterial Agents/ad [Administration & Dosage] | Chronic Disease | Combined Modality Therapy | Debridement/mt [Methods] | Endoscopy | Female | Humans | Male | Middle Aged | Mometasone Furoate | Nebulizers and Vaporizers | Pilot Projects | Pregnadienediols/ad [Administration & Dosage] | Prospective Studies | *Rhinitis/th [Therapy] | *Sinusitis/th [Therapy] | Sodium Chloride/ad [Administration & Dosage] | Therapeutic Irrigation | Treatment OutcomeInstitution(s): MedStar Union Memorial HospitalDepartment(s): Otolaryngology-Head and Neck SurgeryActivity type: Journal Article.Medline article type(s): Controlled Clinical Trial | Journal Article
Abbreviated citation:
Ear Nose Throat J. 93(4-5):E48-54, 2014 Apr-May.
Abstract: The management of refractory chronic rhinosinusitis (CRS) after endoscopic sinus surgery is complex and challenging. We conducted a prospective clinical pilot study to evaluate the effectiveness of a rhinotopic protocol for the treatment of refractory CRS. Our study population was made up of 20 patients--8 men and 12 women, aged 31 to 76 years (mean: 50.1)--who were treated in our tertiary care rhinology fellowship training program. The rhinotopic protocol consisted of twice-daily saline rinses, each of which was followed by the administration of a nebulized corticosteroid and then a nebulized antibiotic. This regimen was administered for 6 weeks. Thereafter, patients underwent a once-weekly endoscopic sinus debridement followed by topical intrasinus installation of a corticosteroid and antibiotic. The duration of follow-up was 24 weeks, and thus the total study duration was 30 weeks. Treatment outcomes were based on Lund-Kennedy symptom scores and Lund-Kennedy endoscopic appearance scores. We found a 56% improvement in the mean symptom score after 3 weeks of therapy and 77% after 6 weeks. Subsequent follow-up revealed 90% improvement 4 weeks following the completion of therapy and 95% at 8 weeks post-therapy. Thereafter, we saw a small decrease in improvement: 73% at 16 weeks of follow-up and 65% at 24 weeks. Analysis of endoscopic appearance scores revealed a 55% improvement at 3 weeks of therapy and 84% at 6 weeks. The same general pattern emerged during follow-up, with 94% improvement 4 weeks after the cessation of therapy, 96% at 8 weeks, 76% at 16 weeks, and 75% at 24 weeks. Sinus cultures performed 4 weeks after the cessation of therapy found no growth in 13 patients (65%), normal respiratory flora in 5 patients (25%), a persistent pathogen in 1 patient (5%), and the emergence of a new pathogen in another (5%). Analysis of symptom scores and endoscopic appearance scores revealed that the rhinotopic protocol resulted in statistically significant improvement (p < 0.001) throughout the treatment period and follow-up period, although the improvement gradually declined over time. We therefore conclude that a rhinotopic protocol can be an effective treatment for refractory CRS.

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