In vivo assessment of placental and brain volumes in growth-restricted fetuses with and without fetal Doppler changes using quantitative 3D MRI.

MedStar author(s):
Citation: Journal of Perinatology. 37(12):1278-1284, 2017 Dec.PMID: 28837138Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology/Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Brain/dg [Diagnostic Imaging] | *Fetal Development | *Fetal Growth Retardation/dg [Diagnostic Imaging] | *Imaging, Three-Dimensional | *Magnetic Resonance Imaging/mt [Methods] | *Placenta/dg [Diagnostic Imaging] | Adolescent | Adult | Brain/pa [Pathology] | Case-Control Studies | Female | Gestational Age | Humans | Longitudinal Studies | Male | Organ Size | Placenta/pa [Pathology] | Predictive Value of Tests | Pregnancy | Prospective Studies | Ultrasonography, Prenatal | Young AdultYear: 2017ISSN:
  • 0743-8346
Name of journal: Journal of perinatology : official journal of the California Perinatal AssociationAbstract: CONCLUSION: Quantitative fetal MRI can accurately detect decreased placental and brain volumes in pregnancies with FGR and may provide insight into the timing and mechanisms of brain injury in FGR.Journal of Perinatology advance online publication, 24 August 2017; doi:10.1038/jp.2017.129.OBJECTIVE: The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR).RESULTS: A total of 114 women (79 controls and 35 FGR) underwent MRI (median gestational age (GA) 30 weeks, range 18 to 39). All measured volumes increased exponentially with advancing GA. Placental, total brain, cerebral and cerebellar volumes were smaller in FGR compared with controls (P<0.05). Increasing placental volume was associated with increasing cerebral and cerebellar volumes (P<0.05).STUDY DESIGN: In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by FGR underwent fetal magnetic resonance imaging (MRI). Placental, global and regional brain volumes were calculated.All authors: Andescavage N, Baschat A, Bulas D, duPlessis A, Iqbal SN, Jacobs M, Limperopoulos C, Metzler M, Vezina GFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-08-29
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Journal Article MedStar Authors Catalog Article 28837138 Available 28837138

CONCLUSION: Quantitative fetal MRI can accurately detect decreased placental and brain volumes in pregnancies with FGR and may provide insight into the timing and mechanisms of brain injury in FGR.Journal of Perinatology advance online publication, 24 August 2017; doi:10.1038/jp.2017.129.

OBJECTIVE: The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR).

RESULTS: A total of 114 women (79 controls and 35 FGR) underwent MRI (median gestational age (GA) 30 weeks, range 18 to 39). All measured volumes increased exponentially with advancing GA. Placental, total brain, cerebral and cerebellar volumes were smaller in FGR compared with controls (P<0.05). Increasing placental volume was associated with increasing cerebral and cerebellar volumes (P<0.05).

STUDY DESIGN: In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by FGR underwent fetal magnetic resonance imaging (MRI). Placental, global and regional brain volumes were calculated.

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