Normal view MARC view ISBD view

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

MedStar author(s):

1061-4036

Name of journal: Nature genetics | Nature geneticsAbstract: To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.All authors: Abbas S, Ahmed N, Alam DS, Anand S, Asma S, Assimes TL, Benn M, Bottinger EP, Butterworth AS, Chambers JC, CHD Exome+ Consortium, Chen P, Chen YI, Chowdhury R, Chung RH, Damrauer S, Danesh J, Di Angelantonio E, EPIC-CVD Consortium, EPIC-Interact Consortium, Epstein S, Frikke-Schmidt R, Frossard P, Guo X, Howson JMM, Hsiung CA, Hsu CC, Hung YJ, Imamura M, Imran A, Iqbal W, Jabeen S, Juang JJ, Jukema JW, Kadowaki T, Kamstrup PR, Kooner JS, Kuo JZ, Lee IT, Lee JJ, Lee WJ, Liang KW, Loos RJF, Lu Y, Maeda S, Majeed F, Malik U, Mallick NH, Mehmood K, Mehra N, Melander O, Memon A, Memon FU, Michigan Biobank, Nielsen SF, Nordestgaard BG, Orho-Melander M, Pare G, Qamar N, Quertermous T, Qureshi IH, Rader DJ, Ralhan S, Rasheed A, Rasheed SZ, Reilly M, Ripatti S, Rizvi SNH, Rotter JI, Saghir T, Saleheen D, Salomaa V, Sanghera DK, Sapkota BR, Sattar N, Shah N, Sheu WH, Small A, Smit R, Surendran P, Tai ES, Tanveer-Us-Salam, Taylor KD, Teo YY, Tikkanen E, Trindade K, Tybjaerg-Hansen A, Voight BF, Wang TD, Yamauch T, Yaqoob Z, Young R, Zhang W, Zhao WFiscal year: FY2018Digital Object Identifier:

https://dx.doi.org/10.1038/ng.3943

Date added to catalog: 2017-09-18

Holdings ( 1 )
Title notes ( 2 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	28869590	Available		28869590

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.

English