MedStar Authors catalog › Details for: Granular cell differentiation: A review of the published work. [Review]
Granular cell differentiation: A review of the published work. [Review] Journal: The Journal of dermatology.Published: 2017ISSN: 0385-2407.UI/PMID: 28256763.Subject(s): *Cell Differentiation | *Granular Cell Tumor/pa [Pathology] | Humans | Neoplasms/pa [Pathology] | Neoplasms/pp [Physiopathology] | Skin Neoplasms/pa [Pathology]Institution(s): MedStar Washington Hospital CenterDepartment(s): DermatologyActivity type: Journal Article.Medline article type(s): Journal Article | ReviewDigital Object Identifier: https://dx.doi.org/10.1111/1346-8138.13758 (Click here) Abbreviated citation: J Dermatol. 44(3):251-258, 2017 Mar.Abstract: Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.Abstract: Copyright © 2017 Japanese Dermatological Association.