MedStar Authors catalog › Details for: Does the disparity in baseline characteristics of patients undergoing transcatheter aortic valve replacement with 23 mm vs. 26 mm valves impact clinical outcome?.
Does the disparity in baseline characteristics of patients undergoing transcatheter aortic valve replacement with 23 mm vs. 26 mm valves impact clinical outcome?. Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. Published: 2016 ISSN: 1522-1946. UI/PMID: 26257081. Subject(s): Aged, 80 and over | Aortic Valve/dg [Diagnostic Imaging] | *Aortic Valve/su [Surgery] | Aortic Valve Stenosis/di [Diagnosis] | *Aortic Valve Stenosis/su [Surgery] | Female | Follow-Up Studies | Humans | Male | Prosthesis Design | Retrospective Studies | Severity of Illness Index | Tomography, X-Ray Computed | *Transcatheter Aortic Valve Replacement/mt [Methods] | Treatment Outcome Institution(s): MedStar Heart & Vascular Institute Activity type: Journal Article. Medline article type(s): Journal Article Digital Object Identifier: https://dx.doi.org/10.1002/ccd.25967 (Click here) Abbreviated citation: Catheter Cardiovasc Interv. 87(1):176-82, 2016 Jan 01. Local Holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006. Abstract: OBJECTIVES: We sought to identify if baseline characteristic differences in patients who receive a 23 mm vs. 26 mm valve impact clinical outcomes. Abstract: BACKGROUND: Transcatheter aortic valve replacement (TAVR) is currently an approved therapy for patients with severe aortic stenosis who are considered inoperable or are at high risk. Abstract: METHODS: We retrospectively examined baseline characteristics and outcomes of patients receiving a 23 mm (n=132) vs. 26 mm valve (n=81) via the transfemoral approach. Abstract: RESULTS: Gender (P<0.01), previous coronary artery bypass surgery (P<0.01), history of atrial fibrillation (P=0.04), and mean Society of Thoracic Surgeons (STS) score (P<0.01) were significantly different between groups. There were no significant differences in the rates of minor/major vascular complications (2.2 vs. 3.7%, P=0.68 and 13.0 vs. 12.3%, P=0.89, respectively). Bleeding complications were also comparable (major bleed 2.3 vs. 1%, P >0.99, minor bleed 19.0 vs. 22.0%, P=0.67 and life threatening bleed 7.0 vs. 5.0%, P=0.77). In-hospital death (6.0 vs. 5.0%, P >0.99), 30-day all-cause death (7.6 vs. 6.2%, P=0.69), and all-cause death at 1 year (17.4 vs. 25.9%, P=0.13) were also similar between groups. Gender, valve size, previous coronary bypass surgery and atrial fibrillation were not independently associated with mortality; however, on multivariate analysis STS score was (HR 1.11; 95% CI 1.02-1.19; P=0.01). Abstract: CONCLUSION: Patients undergoing TAVR with 23 and 26 mm valves have similar clinical outcomes despite significant differences in baseline characteristics. © 2015 Wiley Periodicals, Inc.
Abstract: Copyright © 2015 Wiley Periodicals, Inc.