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The effects of novel, bioresorbable scaffolds on coronary vascular pathophysiology. [Review]

by Escarcega, Ricardo O; Lhermusier, Thibault; Waksman, Ron; Lipinski, Michael J.
Citation: Journal of Cardiovascular Translational Research . 7(4):413-25, 2014 Jun..Journal: Journal of cardiovascular translational research.Full author list: Lipinski MJ; Escarcega RO; Lhermusier T; Waksman R.UI/PMID: 24800874.Subject(s): *Absorbable Implants | Animals | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/pp [Physiopathology] | *Coronary Artery Disease/th [Therapy] | *Coronary Vessels/pp [Physiopathology] | Drug-Eluting Stents | Humans | Percutaneous Coronary Intervention/ae [Adverse Effects] | *Percutaneous Coronary Intervention/is [Instrumentation] | Prosthesis Design | *Stents | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | ReviewDigital Object Identifier: http://dx.doi.org/10.1007/s12265-014-9571-7 (Click here) Abbreviated citation: J Cardiovasc Transl Res. 7(4):413-25, 2014 Jun.Abstract: Percutaneous coronary intervention (PCI) has rapidly evolved over the past 30 years as technology has sought to improve clinical outcomes by addressing pathophysiologic complications arising from the intervention. Stents were designed to resolve the drawbacks of balloon angioplasty by providing radial support to prevent vessel recoil, by sealing coronary dissections, and by preventing abrupt vessel closure. The conceptualization of an ideal drug-eluting fully bioresorbable scaffold (BRS), whether metallic or polymeric, would theoretically address the adverse aspects of permanent metallic stents. In this review of the literature, we will discuss the impact these novel fully BRS platforms have on vascular pathophysiology following PCI.

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