MedStar Authors catalog › Details for: Fetal development in women with diabetes: imprinting for a life-time?.
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Fetal development in women with diabetes: imprinting for a life-time?.

by Feghali, Maisa N; Miodovnik, Menachem.
Citation: Journal of Maternal-Fetal & Neonatal Medicine. 25(1):11-4, 2012 Jan..Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.ISSN: 1476-4954.Full author list: Khoury JC; Dolan LM; Vandyke R; Rosenn B; Feghali M; Miodovnik M.UI/PMID: 21955035.Subject(s): Absorptiometry, Photon | Adiposity | Birth Weight | Blood Glucose/an [Analysis] | Blood Pressure | Body Mass Index | Diabetes Mellitus, Type 1/bl [Blood] | *Diabetes Mellitus, Type 1/co [Complications] | Fasting | Feasibility Studies | Female | Fetal Macrosomia | Follow-Up Studies | Glucose Tolerance Test | Hemoglobin A, Glycosylated/an [Analysis] | Humans | Insulin/bl [Blood] | Male | Pilot Projects | Pregnancy | Pregnancy Trimesters | *Pregnancy in Diabetics | *Prenatal Exposure Delayed Effects | Prospective Studies | Young AdultInstitution(s): MedStar Washington Hospital Center | MedStar Health Research InstituteDepartment(s): Obstetrics and Gynecology/Maternal-Fetal MedicineActivity type: Journal Article.Medline article type(s): Journal Article | Randomized Controlled Trial | Research Support, N.I.H., ExtramuralDigital Object Identifier: http://dx.doi.org/10.3109/14767058.2012.626921 (Click here) Abbreviated citation: J Matern Fetal Neonatal Med. 25(1):11-4, 2012 Jan.Local Holdings: Available online through MWHC library: 2013 to the present.Abstract: OBJECTIVE: To test the hypothesis that fetal exposure to a hyperglycemic intrauterine environment in women with type 1 diabetes is associated with asymmetrically distributed excessive fetal growth and imprinting consistent with adverse health issues later in life.Abstract: METHODS: We report findings from a feasibility study on 19 young adults, born to mothers with type 1 diabetes. Long-term follow-up of the offspring in young adulthood included: oral glucose tolerance test, body mass index (BMI), dual X-ray absorptiometry, and blood pressure (BP). We report z-BMI and z-BP to account for varying gender and age.Abstract: RESULTS: The young adults born to women with diabetes averaged 19.9 years at follow-up; 37% were female, and 21% African American. Maternal glycohemoglobin A(1) concentration in the 2nd trimester was 9.2% for offspring born with asymmetric LGA and 7.5% for those born with symmetric LGA or AGA. There was significant correlation between maternal glucose control during pregnancy and fasting glucose, z-BMI and z-systolic BP in the young adults.Abstract: CONCLUSION: The hyperglycemic intrauterine environment is associated with short-term morbidity, manifested as asymmetric LGA (the "fat" baby). In addition, increasing level of maternal hyperglycemia during pregnancy is associated with increased adiposity and elevated fasting glucose in the young adult offspring.

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