Male Gender Associated with Post-Treatment Seizure Risk of Pediatric Arteriovenous Malformation Patients.

MedStar author(s):
Citation: Neurosurgery. 80(6):899-907, 2017 Jun 01PMID: 28431043Institution: MedStar Washington Hospital CenterDepartment: Medicine/Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Intracranial Arteriovenous Malformations/co [Complications] | *Seizures/ep [Epidemiology] | *Seizures/et [Etiology] | Adolescent | Child | Child, Preschool | Cohort Studies | Female | Humans | Intracranial Arteriovenous Malformations/th [Therapy] | Male | Retrospective Studies | Risk FactorsYear: 2017Local holdings: Available online from MWHC library: 1992 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0148-396X
Name of journal: NeurosurgeryAbstract: BACKGROUND: Seizure risk has not been fully characterized in pediatric patients with arteriovenous malformations (AVMs).CONCLUSION: Risk of seizure persists after treatment in pediatric AVM patients. Seizure presentation, male gender, and nonconservative management are associated with increased risk of post-treatment seizure. Early identification of these risk factors provides important information for determining seizure management strategies.METHODS: We retrospectively reviewed pediatric patients diagnosed with intracranial AVMs at our institution between 1990 and 2013. Clinical and angiographic variables were included in univariate and multivariate Cox proportional hazard models to explore risk factors associated with time-related seizure outcomes. The outcome event is defined as first seizure occurrence after initial treatment. Kaplan-Meier survival curve is depicted for each significant variable, and survival differences were confirmed by Log-rank test.OBJECTIVE: To describe the progression and risk factors of post-treatment seizure in children with AVMs.RESULTS: We included 90 pediatric patients with complete data in our study cohort. Average age is 13.3 +/- 3.8 years with 43.3% male patients. Thirty-seven patients had a hemorrhagic presentation, and 39 patients presented with seizure. Post-treatment seizure occurred in 33 patients (36.7%) over an average follow-up period of 8.1 +/- 10.6 years; average time to onset is 5.3 +/- 8.2 years, with partial seizures as the most common presentation. Multivariate Cox proportional hazard regression revealed seizure presentation ( P = .005), male gender ( P = .026), and nonconservative treatment modality to be significantly associated with earlier onset of post-treatment seizure after adjusting for AVM location and deep venous drainage. Overall annualized seizure risk is 7.4% for patients with pretreatment seizure, and 1.4% for those without.All authors: Ahn ES, Anderson-Keightly H, Braileanu M, Caplan JM, Colby GP, Coon AL, Huang J, Hung AL, Rong X, Tamargo RJ, Wang JY, Westbroek EM, Yang WFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-05-06
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 28431043 Available 28431043

Available online from MWHC library: 1992 - present, Available in print through MWHC library: 1999 - 2006

BACKGROUND: Seizure risk has not been fully characterized in pediatric patients with arteriovenous malformations (AVMs).

CONCLUSION: Risk of seizure persists after treatment in pediatric AVM patients. Seizure presentation, male gender, and nonconservative management are associated with increased risk of post-treatment seizure. Early identification of these risk factors provides important information for determining seizure management strategies.

METHODS: We retrospectively reviewed pediatric patients diagnosed with intracranial AVMs at our institution between 1990 and 2013. Clinical and angiographic variables were included in univariate and multivariate Cox proportional hazard models to explore risk factors associated with time-related seizure outcomes. The outcome event is defined as first seizure occurrence after initial treatment. Kaplan-Meier survival curve is depicted for each significant variable, and survival differences were confirmed by Log-rank test.

OBJECTIVE: To describe the progression and risk factors of post-treatment seizure in children with AVMs.

RESULTS: We included 90 pediatric patients with complete data in our study cohort. Average age is 13.3 +/- 3.8 years with 43.3% male patients. Thirty-seven patients had a hemorrhagic presentation, and 39 patients presented with seizure. Post-treatment seizure occurred in 33 patients (36.7%) over an average follow-up period of 8.1 +/- 10.6 years; average time to onset is 5.3 +/- 8.2 years, with partial seizures as the most common presentation. Multivariate Cox proportional hazard regression revealed seizure presentation ( P = .005), male gender ( P = .026), and nonconservative treatment modality to be significantly associated with earlier onset of post-treatment seizure after adjusting for AVM location and deep venous drainage. Overall annualized seizure risk is 7.4% for patients with pretreatment seizure, and 1.4% for those without.

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