Impact on mortality of coronary and non-coronary cardiovascular findings in non-gated thoracic CT by malignancy status.

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Citation: European Journal of Radiology. 93:169-177, 2017 AugPMID: 28668412Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Coronary Artery Disease/mo [Mortality] | *Neoplasms/mo [Mortality] | *Vascular Calcification/mo [Mortality] | Adult | Aged | Coronary Artery Disease/dg [Diagnostic Imaging] | Female | Humans | Male | Middle Aged | Plaque, Atherosclerotic/mo [Mortality] | Predictive Value of Tests | Prognosis | Radiography, Thoracic/mo [Mortality] | Radiography, Thoracic/mt [Methods] | Risk Assessment/mt [Methods] | Risk Factors | Survival Rate | Tomography, X-Ray Computed/mo [Mortality] | Tomography, X-Ray Computed/mt [Methods] | Vascular Calcification/dg [Diagnostic Imaging]Year: 2017ISSN:
  • 0720-048X
Name of journal: European journal of radiologyAbstract: CONCLUSIONS: In this study including clinically indicated non-gated standard thoracic CT scans, survival rates were associated to the CAC extension among patients without malignancy, and to the NCACVF class independent from the malignancy status.Copyright (c) 2017 Elsevier B.V. All rights reserved.MATERIALS AND METHODS: Between August and December 2012, a total of 1.901 patients aged between 35 and 74 years underwent clinically indicated non-gated, non-enhanced thoracic CT scans and followed for mortality through September 2016.PURPOSE: The prognostic value of coronary artery calcification (CAC) assessed on non-gated thoracic CT scans has only been explored in population-based studies. We explored the impact of the presence and extension of CAC, as well as of non-coronary atherosclerosis cardiovascular findings (NCACVF) in survival of patients with and without malignancies undergoing clinically indicated non-gated thoracic computed tomography (CT) scans.RESULTS: Three hundred and thirty two (17.5%), 250 (13.2%), and 329 (17.3%) patients showed CAC in 1, 2, and 3 vessels, respectively, and the remaining had no CAC. Two hundred and fifty five (13.4%) patients had evidence of extensive calcification (CACSIS>5). Only 62 (3.3%) had major NCACVF whereas 1635 (86%) had none or minimal NCACVF. After a median follow-up of 3.7 (3.5-3.9) years, 217 (11.4%) deaths occurred. Age [HR 1.03 (95% CI 1.01-1.05), p=0.001], a history of malignancy [HR 8.04 (95% CI 5.95-10.9), p<0.0001], and the NCACVF class [HR 1.79 (95% CI 1.45-2.19), p<0.0001] were identified as independent predictors of death. CACSIS was found an independent predictor of death only among patients without malignancy (HR 1.10 (95% CI 1.02-1.20), p=0.019).All authors: Capunay C, Carrascosa P, Garcia-Garcia HM, Reynoso E, Rodriguez-Granillo GAFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-07-10
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Journal Article MedStar Authors Catalog Article 28668412 Available 28668412

CONCLUSIONS: In this study including clinically indicated non-gated standard thoracic CT scans, survival rates were associated to the CAC extension among patients without malignancy, and to the NCACVF class independent from the malignancy status.

Copyright (c) 2017 Elsevier B.V. All rights reserved.

MATERIALS AND METHODS: Between August and December 2012, a total of 1.901 patients aged between 35 and 74 years underwent clinically indicated non-gated, non-enhanced thoracic CT scans and followed for mortality through September 2016.

PURPOSE: The prognostic value of coronary artery calcification (CAC) assessed on non-gated thoracic CT scans has only been explored in population-based studies. We explored the impact of the presence and extension of CAC, as well as of non-coronary atherosclerosis cardiovascular findings (NCACVF) in survival of patients with and without malignancies undergoing clinically indicated non-gated thoracic computed tomography (CT) scans.

RESULTS: Three hundred and thirty two (17.5%), 250 (13.2%), and 329 (17.3%) patients showed CAC in 1, 2, and 3 vessels, respectively, and the remaining had no CAC. Two hundred and fifty five (13.4%) patients had evidence of extensive calcification (CACSIS>5). Only 62 (3.3%) had major NCACVF whereas 1635 (86%) had none or minimal NCACVF. After a median follow-up of 3.7 (3.5-3.9) years, 217 (11.4%) deaths occurred. Age [HR 1.03 (95% CI 1.01-1.05), p=0.001], a history of malignancy [HR 8.04 (95% CI 5.95-10.9), p<0.0001], and the NCACVF class [HR 1.79 (95% CI 1.45-2.19), p<0.0001] were identified as independent predictors of death. CACSIS was found an independent predictor of death only among patients without malignancy (HR 1.10 (95% CI 1.02-1.20), p=0.019).

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