Citation: Eurointervention. 12(1):88-93, 2016 May 17.Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.Published: 2016ISSN: 1774-024X.Full author list: Kiramijyan S; Magalhaes MA; Ben-Dor I; Koifman E; Escarcega RO; Baker NC; Torguson R; Okubagzi P; Bernardo NL; Satler LF; Pichard AD; Waksman R.UI/PMID: 27173868.Subject(s): Aged | Aged, 80 and over | *Aortic Valve/su [Surgery] | *Aortic Valve Stenosis/su [Surgery] | Cardiac Catheterization/mt [Methods] | Female | *Femoral Artery/su [Surgery] | Heart Valve Prosthesis/ae [Adverse Effects] | Heart Valve Prosthesis Implantation/mt [Methods] | *Heart Valve Prosthesis Implantation | Hemostatic Techniques/ae [Adverse Effects] | Humans | Male | Retrospective Studies | Transcatheter Aortic Valve Replacement/mt [Methods] | *Transcatheter Aortic Valve Replacement | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.4244/EIJV12I1A16 (Click here)Abbreviated citation: EuroIntervention. 12(1):88-93, 2016 May 17.Abstract: AIMS: The objective of this study was to describe and evaluate the adjunctive technique of Angio-Seal (AS) use to augment the dual Perclose ProGlide (PP) in achieving haemostasis in patients undergoing transfemoral percutaneous transcatheter aortic valve replacement (TAVR).Abstract: METHODS AND RESULTS: All patients who underwent TAVR from May 2007 to January 2015 via a planned transfemoral percutaneous approach with a dual PP pre-close strategy were retrospectively analysed. This cohort was divided into two groups: dual PP versus dual PP with adjunctive AS (PP+AS) use based on the specific status of intraprocedural haemostasis. The baseline and procedural characteristics and in-hospital outcomes were prospectively collected and retrospectively compared. Overall, a total of 387 consecutive patients (55% male, mean age 83 years) with dual PP (n=179) vs. dual PP+AS (n=208) were evaluated. There were no statistically significant differences between the dual PP vs. dual PP+AS groups with regard to the in-hospital Valve Academic Research Consortium-2 (VARC-2) primary endpoints of major vascular complications (8.0% vs. 6.6%, p=0.592), minor vascular complications (18.4% vs. 13.7%, p=0.218), life-threatening or disabling bleeding (5.1% vs. 3.0%, p=0.291), major bleeding (1.7% vs. 1.5%, p=1.000), and minor bleeding (14.4% vs. 10.6%, p=0.271).Abstract: CONCLUSIONS: The adjunctive Angio-Seal technique to augment the dual PP pre-close strategy for patients undergoing percutaneous femoral closure following TAVR is feasible and safe and may be considered as a bail-out or an alternative strategy when the dual PP closure technique fails to obtain complete haemostasis.