MedStar Authors catalog › Details for: ICU-Acquired Weakness: A Rehabilitation Perspective of Diagnosis, Treatment, and Functional Management. [Review]
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ICU-Acquired Weakness: A Rehabilitation Perspective of Diagnosis, Treatment, and Functional Management. [Review]

by Zorowitz, Richard D.
Citation: Chest. 150(4):966-971, 2016 Oct.Journal: Chest.Published: 2016ISSN: 0012-3692.Full author list: Zorowitz RD.UI/PMID: 27312737.Subject(s): Activities of Daily Living | *Critical Illness/rh [Rehabilitation] | Electromyography | Glucocorticoids/tu [Therapeutic Use] | Humans | Hyperglycemia/dt [Drug Therapy] | Hyperglycemia/ep [Epidemiology] | Hypoglycemic Agents/tu [Therapeutic Use] | Immobilization/sn [Statistics & Numerical Data] | Inflammation/ep [Epidemiology] | Insulin/tu [Therapeutic Use] | *Intensive Care Units | Long-Term Care | Multiple Organ Failure/ep [Epidemiology] | Muscle Weakness/di [Diagnosis] | Muscle Weakness/ep [Epidemiology] | *Muscle Weakness/rh [Rehabilitation] | Muscular Diseases/di [Diagnosis] | Muscular Diseases/ep [Epidemiology] | *Muscular Diseases/rh [Rehabilitation] | Neural Conduction | Neurologic Examination | Neuromuscular Blocking Agents/tu [Therapeutic Use] | Polyneuropathies/di [Diagnosis] | Polyneuropathies/ep [Epidemiology] | *Polyneuropathies/rh [Rehabilitation] | Rehabilitation Centers | Risk Factors | Sepsis/ep [Epidemiology]Institution(s): MedStar National Rehabilitation NetworkActivity type: Journal Article.Medline article type(s): Journal Article | ReviewDigital Object Identifier: (Click here) Abbreviated citation: Chest. 150(4):966-971, 2016 Oct.Local Holdings: Available online from MWHC library: 1935 - present, Available in print through MWHC library: 1999 - 2006.Abstract: ICU-acquired weakness (ICUAW) occurs with reported incidence rates from 25% to 100%. Risk factors include immobility, sepsis, persistent systemic inflammation, multiorgan system failure, hyperglycemia, glucocorticoids, and neuromuscular blocking agents. The pathophysiology remains unknown. Clinical features may be neuropathic, myopathic, or a combination of both. Although manual muscle testing is more practical in diagnosing ICUAW, the "gold standard" for the diagnosis of ICUAW remains electromyography and nerve conduction studies. The only potential interventions known to date to prevent ICUAW include insulin therapy and early rehabilitation, but patients still may develop activity limitations in the acute care hospital. For these patients, rehabilitation may continue in long-term care hospitals, inpatient rehabilitation facilities, or skilled nursing facilities. ICUAW is a catastrophic and debilitating condition that potentially leaves patients with permanent residual activity limitations and participation restrictions. Further research on ICUAW needs to better understand its pathophysiology so that more definitive preventive and therapeutic interventions may be developed.Abstract: Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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