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When there is no match, the game is not over: Alternative donor options for hematopoietic stem cell transplantation in sickle cell disease. [Review]

MedStar author(s):

Citation: Seminars in Hematology. 55(2):94-101, 2018 Apr.PMID: 29958565Institution: MedStar Washington Hospital CenterDepartment: Hematology and OncologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2018 Local holdings: Available online from MWHC library: 2002 - 2008, Available in print through MWHC library: 1999 - presentISSN:

0037-1963

Name of journal: Seminars in hematologyAbstract: Copyright Published by Elsevier Inc.Many patients with sickle cell disease experience severe morbidity and early mortality. The only curative option remains hematopoietic stem cell transplantation. Although HLA-matched sibling transplantation has been very successful for adults and children, the vast majority of patients with sickle cell disease do not have an HLA-matched sibling. Alternative donor options include haploidentical, unrelated umbilical cord blood, and matched unrelated donor transplantation. This report summarizes major alternative donor transplantation studies reported to date and ongoing and upcoming clinical trials. We conclude that when there is no HLA-match, all these approaches should be systematically considered before ruling out the option of hematopoietic stem cell transplantation.All authors: Abraham AA, Fitzhugh CD, Joseph JJFiscal year: FY2018Digital Object Identifier:

https://dx.doi.org/10.1053/j.seminhematol.2018.04.013

Date added to catalog: 2018-07-30

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	29958565	Available		29958565

Available online from MWHC library: 2002 - 2008, Available in print through MWHC library: 1999 - present

Many patients with sickle cell disease experience severe morbidity and early mortality. The only curative option remains hematopoietic stem cell transplantation. Although HLA-matched sibling transplantation has been very successful for adults and children, the vast majority of patients with sickle cell disease do not have an HLA-matched sibling. Alternative donor options include haploidentical, unrelated umbilical cord blood, and matched unrelated donor transplantation. This report summarizes major alternative donor transplantation studies reported to date and ongoing and upcoming clinical trials. We conclude that when there is no HLA-match, all these approaches should be systematically considered before ruling out the option of hematopoietic stem cell transplantation.

English