Impact of statins preloading before PCI on periprocedural myocardial infarction among stable angina pectoris patients undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials. [Review]

MedStar author(s):
Citation: Cardiovascular Revascularization Medicine. 19(8):971-975, 2018 12.PMID: 30056022Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Angina, Stable/dt [Drug Therapy] | *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use] | *Myocardial Infarction/th [Therapy] | *Percutaneous Coronary Intervention | *Postoperative Complications/pc [Prevention & Control] | *Preoperative Care/mt [Methods] | *Randomized Controlled Trials as Topic | Angina, Stable/et [Etiology] | Global Health | Humans | Morbidity | Myocardial Infarction/co [Complications] | Postoperative Complications/ep [Epidemiology] | Survival RateYear: 2018Local holdings: Available in print through MWHC library: 2002 - presentISSN:
  • 1878-0938
Name of journal: Cardiovascular revascularization medicine : including molecular interventionsAbstract: Copyright (c) 2018 Elsevier Inc. All rights reserved.It has been shown that statins preloading, before percutaneous coronary intervention (PCI), may reduce the risk of cardiovascular outcomes for acute coronary syndrome patients. Nevertheless, the effect of such pretreatment among patients with stable angina pectoris (SAP) is still debatable. We performed a systematic review and updated meta-analysis of the literature to evaluate the efficacy of short-term statins preloading on periprocedural myocardial infarction (PMI) incidence and mortality after PCI. We included 13 randomized control trials that examined statins preloading in adult patients with SAP undergoing PCI. While the use of preloading statins significantly reduced PMI, the benefit of statins pretreatment on long-term mortality was not statistically significant.SHORT SUMMARY: High dose statins preloading prior to elective PCI was associated with a significant reduction in PMI in SAP patients. The mortality benefit of such intervention will need to be addressed by further large randomized studies. The routine use of statins in stable patients before PCI should be considered if no contraindications are present.All authors: Garcia-Garcia HM, Hideo-Kajita A, Ho G, Kuku KO, Soud M, Waksman RFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2018-08-02
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 30056022 Available 30056022

Available in print through MWHC library: 2002 - present

Copyright (c) 2018 Elsevier Inc. All rights reserved.

It has been shown that statins preloading, before percutaneous coronary intervention (PCI), may reduce the risk of cardiovascular outcomes for acute coronary syndrome patients. Nevertheless, the effect of such pretreatment among patients with stable angina pectoris (SAP) is still debatable. We performed a systematic review and updated meta-analysis of the literature to evaluate the efficacy of short-term statins preloading on periprocedural myocardial infarction (PMI) incidence and mortality after PCI. We included 13 randomized control trials that examined statins preloading in adult patients with SAP undergoing PCI. While the use of preloading statins significantly reduced PMI, the benefit of statins pretreatment on long-term mortality was not statistically significant.

SHORT SUMMARY: High dose statins preloading prior to elective PCI was associated with a significant reduction in PMI in SAP patients. The mortality benefit of such intervention will need to be addressed by further large randomized studies. The routine use of statins in stable patients before PCI should be considered if no contraindications are present.

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