MedStar Authors catalog › Details for: A clinical trial with culturally appropriate video to increase participation of African Americans in cancer clinical trials.
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A clinical trial with culturally appropriate video to increase participation of African Americans in cancer clinical trials.

by Banda, D R; Mete, Mihriye; Swain, Sandra M.
Citation: Journal of Clinical Oncology. 29(27_suppl):159, 2011 Sep 20.Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology.Published: 2011ISSN: 0732-183X.Full author list: Banda DR; Mete M; Swain SM.UI/PMID: 27957972.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Health Research Institute | Washington Cancer InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: J Clin Oncol. 29(27_suppl):159, 2011 Sep 20.Local Holdings: Available online from MWHC library: 1999 - present, Available in print through MWHC library: 1999 - 2008.Abstract: 159 Background: There is a need to develop patient-level interventions to change attitudes and increase African American (AA) participation in breast cancer clinical trials (CT). This pilot study tested the efficacy of a 15 minute narrative-based video which we created in the first such intervention in AA patients.Abstract: METHODS: This single group study enrolled 88 breast cancer patients in active treatment at a large urban cancer institute. Eligible patients were self-identified AA, >= 21 years, and never participated in a CT. The primary outcome was self-reported likelihood to enroll in a therapeutic CT. Participants were interviewed at baseline using an instrument developed specifically to assess attitudes on six trial barriers. An immediate post-test was administered following the video. McNemar's test for matched pairs was used to assess the change in likelihood to enroll in a CT. Stuart-Maxwell marginal homogeneity test for matched pairs with multi-category outcomes was used to evaluate which attitudes were impacted by the intervention.Abstract: RESULTS: Patients enrolled October 2010- February 2011 (n =108), 75% female. Age from 31-87 years, mean 61 (SD=12). Patients' likelihood of enrolling in a CT significantly increased post video [OR 19.5, 95% CI: 5.05 - 166.7, McNemar's chi<sup>2</sup> = 33.39, P <0.001]. Stuart-Maxwell tests showed significant changes in 28 of 30 attitudinal questions post video. Specifically, the video impacted attitudes associated with a concern about the ethical conduct of investigators; the fear of loss of autonomy after signing an informed consent form; worry about being treated poorly as a poor or minority patient; loss of privacy; and the lack of knowledge and awareness of clinical trials.Abstract: CONCLUSIONS: These data demonstrate the overall efficacy of our video and can be extrapolated to a single disease focus. This should have particular benefit for large cooperative group studies including breast cancer trials.

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