MedStar Authors catalog › Details for: Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS).
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Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS).

by Aroda, Vanita R.
Citation: Diabetic Medicine. 34(12):1747-1755, 2017 Dec..Journal: Diabetic medicine : a journal of the British Diabetic Association.Published: 2017ISSN: 0742-3071.Full author list: Perreault L; Pan Q; Aroda VR; Barrett-Connor E; Dabelea D; Dagogo-Jack S; Hamman RF; Kahn SE; Mather KJ; Knowler WC; The Diabetes Prevention Program Research Group.UI/PMID: 28833481.Subject(s): Adult | *Diabetes Mellitus, Type 2/co [Complications] | Diabetes Mellitus, Type 2/ep [Epidemiology] | *Diabetes Mellitus, Type 2/pc [Prevention & Control] | Diabetic Angiopathies/ep [Epidemiology] | *Diabetic Angiopathies/pc [Prevention & Control] | Diet, Reducing | Exercise Therapy | Female | Follow-Up Studies | Humans | Male | Metformin/tu [Therapeutic Use] | Middle Aged | Obesity/co [Complications] | Obesity/ep [Epidemiology] | *Obesity/th [Therapy] | Overweight/co [Complications] | Overweight/ep [Epidemiology] | *Overweight/th [Therapy] | Prediabetic State/co [Complications] | Prediabetic State/ep [Epidemiology] | Prediabetic State/pa [Pathology] | *Prediabetic State/th [Therapy] | Prevalence | Risk Factors | Risk Reduction Behavior | Treatment Outcome | Weight Reduction Programs/mt [Methods] | *Weight Reduction ProgramsInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1111/dme.13453 (Click here) Abbreviated citation: Diabet Med. 34(12):1747-1755, 2017 Dec.Local Holdings: Available online from MWHC library: 2001 - present, Available in print through MWHC library: 1999 - 2006.Abstract: AIM: Approximately half of the participants in the Diabetes Prevention Outcomes Study (DPPOS) had diabetes after 15 years of follow-up, whereas nearly all the others remained with pre-diabetes. We examined whether formerly unexplored factors in the DPPOS coexisted with known risk factors that posed additional risk for, or protection from, diabetes as well as microvascular disease.Abstract: METHODS: Cox proportional hazard models were used to examine predictors of diabetes. Sequential modelling procedures considered known and formerly unexplored factors. We also constructed models to determine whether the same unexplored factors that associated with progression to diabetes also predicted the prevalence of microvascular disease. Hazard ratios (HR) are per standard deviation change in the variable.Abstract: RESULTS: In models adjusted for demographics and known diabetes risk factors, two formerly unknown factors were associated with risk for both diabetes and microvascular disease: number of medications taken (HR = 1.07, 95% confidence intervals (95% CI) 1.03 to 1.12 for diabetes; odds ratio (OR) = 1.10, 95% CI 1.04 to 1.16 for microvascular disease) and variability in HbA<sub>1c</sub> (HR = 1.02, 95% CI 1.01 to 1.03 for diabetes; OR = 1.06, 95% CI 1.04 to 1.09 for microvascular disease per sd). Total comorbidities increased risk for diabetes (HR = 1.10, 95% CI 1.04 to 1.16), whereas higher systolic (OR = 1.22, 95% CI 1.13 to 1.31) and diastolic (OR = 1.14, 95% CI 1.05 to 1.22) blood pressure, as well as the use of anti-hypertensives (OR = 1.41, 95% CI 1.23 to 1.62), increased risk of microvascular disease.Abstract: CONCLUSIONS: Several formerly unexplored factors in the DPPOS predicted additional risk for diabetes and/or microvascular disease - particularly hypertension and the use of anti-hypertensive medications - helping to explain some of the residual disease risk in participants of the DPPOS. (Clinical Trial Registry Nos: DPP NCT00004992 and DPPOS NCT00038727) This article is protected by copyright. All rights reserved.

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