Citation: Frontiers in Surgery. 4:42, 2017.Journal: Frontiers in surgery.Published: 2017ISSN: 2296-875X.Full author list: Quadri HS; Smaglo BG; Morales SJ; Phillips AC; Martin AD; Chalhoub WM; Haddad NG; Unger KR; Levy AD; Al-Refaie WB.UI/PMID: 28824918.Subject(s): PubMed-not-MEDLINE -- Not indexedInstitution(s): MedStar Washington Hospital Center | MedStar Health Research InstituteDepartment(s): Surgery/General SurgeryActivity type: Journal Article.Medline article type(s): Journal Article | ReviewOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.3389/fsurg.2017.00042 (Click here)Abbreviated citation: Front. surg.. 4:42, 2017.Abstract: Despite its declining incidence, gastric cancer (GC) remains a leading cause of cancer-related deaths worldwide. A multimodal approach to GC is critical to ensure optimal patient outcomes. Pretherapy fine resolution contrast-enhanced cross-sectional imaging, endoscopic ultrasound and staging laparoscopy play an important role in patients with newly diagnosed ostensibly operable GC to avoid unnecessary non-therapeutic laparotomies. Currently, margin negative gastrectomy and adequate lymphadenectomy performed at high volume hospitals remain the backbone of GC treatment. Importantly, adequate GC surgery should be integrated in the setting of a multimodal treatment approach. Treatment for advanced GC continues to expand with the emergence of additional lines of systemic and targeted therapies.