Citation: American Journal of Cardiology. 120(4):632-639, 2017 Aug 15.Journal: The American journal of cardiology.Published: 2017ISSN: 0002-9149.Full author list: Koifman E; Didier R; Garcia-Garcia H; Weissman G; Ertel AW; Kiramijyan S; Steinvil A; Rogers T; Patel N; Kumar S; Tavil-Shatelyan A; Ben-Dor I; Pichard AD; Torguson R; Gai J; Satler LF; Waksman R.UI/PMID: 28673639.Subject(s): Aged, 80 and over | Aortic Valve Insufficiency/di [Diagnosis] | Aortic Valve Insufficiency/et [Etiology] | *Aortic Valve Insufficiency/su [Surgery] | *Aortic Valve Stenosis/su [Surgery] | *Balloon Valvuloplasty/mt [Methods] | Female | Fluoroscopy | Follow-Up Studies | *Heart Valve Prosthesis/ae [Adverse Effects] | Humans | Male | *Postoperative Complications | Reoperation | Retrospective Studies | Risk Factors | Severity of Illness Index | *Transcatheter Aortic Valve Replacement/ae [Adverse Effects]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S000291491730869Xhttps://dx.doi.org/10.1016/j.amjcard.2017.05.033 (Click here) | (Click here)Abbreviated citation: Am J Cardiol. 120(4):632-639, 2017 Aug 15.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: We aimed to evaluate the success rates of balloon valvuloplasty post-dilation (BVPD) and a second-valve deployment in reducing residual aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and its impact on outcome. Residual AR immediately post-TAVI in patients with aortic stenosis is a common condition that adversely affects outcome. Patients who underwent TAVI who had more-than-mild residual AR were managed either with medical therapy, re-intervention with BVPD, or a second valve. The clinical impact of these strategies was evaluated, and the anatomical features of patients with successful and unsuccessful intervention were compared. Among 572 patients with TAVI, 110 (19%) had significant residual AR after initial device deployment. Sixty patients were treated by BVPD (n = 49) or second-device deployment (n = 11), whereas 50 patients were treated medically. Successful reduction in residual AR to mild and below was achieved in 56% of the intervention group. Eccentric and calcified annuli were present in patients in whom residual AR remained despite re-intervention (p = 0.004). Interventions to reduce residual AR were independently associated with improved survival compared with conservative medical therapy (hazard ratio 0.45, 95% confidence interval 0.94 to 0.21, p = 0.03). BVPD or a second valve were safe and were not associated with increased rate of periprocedural complications. In conclusion, both BVPD and a second-valve deployment to reduce residual AR post-TAVI are effective and safe. The success rates are inversely correlated with the annulus eccentricity and calcification. These measures should be encouraged to reduce acute residual AR as they are associated with improved long-term survival.Abstract: Copyright (c) 2017. Published by Elsevier Inc.