Citation: Journal of the American College of Cardiology. 61(7):728-37, 2013 Feb 19..Journal: Journal of the American College of Cardiology.Published: 2013ISSN: 0735-1097.Full author list: Blum S; Cahill LE; Chiuve SE; Howard BV; Jensen MK; Levy AP; Mukamal KJ; Pai JK; Rexrode KM; Rimm EB; Shara NM; Wang H.UI/PMID: 23312704.Subject(s): *Coronary Disease/ge [Genetics] | *Genotype | *Haptoglobins/ge [Genetics] | *Haptoglobins/me [Metabolism] | *Hemoglobin A, Glycosylated/ge [Genetics] | Adult | Aged | Aged, 80 and over | Biological Markers/bl [Blood] | Case-Control Studies | Cohort Studies | Coronary Disease/bl [Blood] | Female | Glycosylation | Hemoglobin A, Glycosylated/me [Metabolism] | Humans | Male | Middle Aged | Prospective Studies | Risk Factors | Up-Regulation/ge [Genetics] | Young AdultInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Randomized Controlled Trial | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tOnline resources: Click here to access onlineDigital Object Identifier: (Click here)Abbreviated citation: J Am Coll Cardiol. 61(7):728-37, 2013 Feb 19.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007.Abstract: BACKGROUND: Studies of the association between the Hp polymorphism and CHD report inconsistent results. Individuals with the Hp2-2 genotype produce Hp proteins with an impaired ability to prevent oxidative injury caused by elevated HbA(1c).Abstract: CONCLUSIONS: Hp genotype was a significant predictor of CHD among individuals with elevated HbA(1c). Copyright 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.Abstract: METHODS: HbA(1c) concentration and Hp genotype were determined for 407 CHD cases matched 1:1 to controls (from the NHS [Nurses' Health Study]) and in a replication cohort of 2,070 individuals who served as the nontreatment group in the ICARE (Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment) study, with 29 CHD events during follow-up. Multivariate models were adjusted for lifestyle and CHD risk factors as appropriate. A pooled analysis was conducted of NHS, ICARE, and the 1 previously published analysis (a cardiovascular disease case-control sample from the Strong Heart Study).Abstract: OBJECTIVES: This study sought to investigate into the biologically plausible interaction between the common haptoglobin (Hp) polymorphism rs#72294371 and glycosylated hemoglobin (HbA(1c)) on risk of coronary heart disease (CHD).Abstract: RESULTS: In the NHS, Hp2-2 genotype (39% frequency) was strongly related to CHD risk only among individuals with elevated HbA(1c) (>= 6.5%), an association that was similar in the ICARE trial and the Strong Heart Study. In a pooled analysis, participants with both the Hp2-2 genotype and elevated HbA(1c) had a relative risk of 7.90 (95% confidence interval: 4.43 to 14.10) for CHD compared with participants with both an Hp1 allele and HbA(1c) <6.5% (p for interaction = 0.004), whereas the Hp2-2 genotype with HbA(1c) <6.5% was not associated with risk (relative risk: 1.34 [95% confidence interval: 0.73 to 2.46]).