Citation: NPJ Breast Cancer. 3:36, 2017.Journal: NPJ breast cancer.Published: 2017ISSN: 2374-4677.Full author list: Robinson BN; Newman AF; Tefera E; Herbolsheimer P; Nunes R; Gallagher C; Randolph-Jackson P; Omogbehin A; Dilawari A; Pohlmann PR; Mohebtash M; Lee Y; Ottaviano Y; Mohapatra A; Lynce F; Brown R; Mete M; Swain SM.UI/PMID: 28944289.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): Washington Cancer Institute | MedStar Health Research Institute | MedStar Franklin Square Medical Center | MedStar Union Memorial Hospital | MedStar Harbor HospitalActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1038/s41523-017-0039-1 (Click here)ORCID: Swain, Sandra M https://orcid.org/0000-0002-1320-3830 (Click here)Abbreviated citation: NPJ Breast Cancer. 3:36, 2017.Abstract: There is a striking racial and ethnic disparity in incidence and mortality of cancer yet minorities remain markedly underrepresented in clinical trials. This pilot study set out to determine the impact of a 15-min culturally tailored educational video on three outcomes relating to clinical trials: likely participation, attitudes (assessed based on six barriers), and actual enrollment. Breast cancer patients with Stage I-III, if diagnosed within previous 6 months, or metastatic disease who self-identified as black or African American were invited to participate. The primary outcome measure was the decision to participate in a therapeutic clinical trial after the intervention. Patients' intention to enroll on a therapeutic clinical trial and the change in attitudes toward clinical trials were measured by the previously developed Attitudes and Intention to Enroll in Therapeutic Clinical Trials (AIET) questionnaire. Of the 200 patients that participated, 39 (19.5%) patients signed consent to participate in a therapeutic clinical trial; 27 (13.5%) patients enrolled, resulting in a 7.5% increase from our baseline comparison of 6% clinical trial enrollment rate in black cancer patients (p<.001). Pre-test versus post-test assessment demonstrated the proportion of patients expressing likelihood to enroll in a therapeutic trial following the intervention increased by 14% (p<.001). Among 31 AIET items, 25 (81%) showed statistically significant and positive change post-intervention. The findings suggest the promising utility of a culturally tailored video intervention for improving black patients' attitudes regarding clinical trial participation and resultant enrollment. Future efforts should continue to target facilitators of population-specific recruitment, enrollment, and retention in therapeutic and non-therapeutic clinical trials.