MedStar Authors catalog › Details for: Incremental value of biochemical and echocardiographic measures in prediction of ischemic stroke: the Strong Heart Study.
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Incremental value of biochemical and echocardiographic measures in prediction of ischemic stroke: the Strong Heart Study.

by Howard, Barbara V; Umans, Jason G.
Citation: Stroke. 43(3):720-6, 2012 Mar..Journal: Stroke; a journal of cerebral circulation.ISSN: 0039-2499.Full author list: Karas MG; Devereux RB; Wiebers DO; Whisnant JP; Best LG; Lee ET; Howard BV; Roman MJ; Umans JG; Kizer JR.UI/PMID: 22207511.Subject(s): Aged | Albuminuria/co [Complications] | Brain Ischemia/co [Complications] | *Brain Ischemia/me [Metabolism] | Brain Ischemia/us [Ultrasonography] | C-Reactive Protein/an [Analysis] | Cardiovascular Diseases/co [Complications] | Cohort Studies | Creatinine/ur [Urine] | Data Interpretation, Statistical | *Echocardiography/sn [Statistics & Numerical Data] | Female | Fibrinogen/an [Analysis] | Follow-Up Studies | *Heart/ph [Physiology] | Heart Atria | Hemoglobin A, Glycosylated/an [Analysis] | Humans | Indians, North American | Kidney Diseases/co [Complications] | Male | Middle Aged | Risk Factors | Stroke/et [Etiology] | *Stroke/me [Metabolism] | Stroke/us [Ultrasonography]Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: Stroke. 43(3):720-6, 2012 Mar.Local Holdings: Available online from MWHC library: 1970 - present, Available in print through MWHC library: 1999 - 2006.Abstract: BACKGROUND AND PURPOSE: American Indians have high rates of stroke. Improved risk stratification could enhance prevention, but the ability of biochemical and echocardiographic markers of preclinical disease to improve stroke prediction is not well-defined.Abstract: METHODS: We evaluated such markers as predictors of ischemic stroke in a community-based cohort of American Indians without prevalent cardiovascular or renal disease. Laboratory markers included C-reactive protein, fibrinogen, urine albumin-to-creatinine ratio, and glycohemoglobin (HbA1c), whereas echocardiographic parameters comprised left atrial diameter, left ventricular mass, mitral annular calcification, and the ratio of early to late mitral diastolic velocities. Predictive performance was judged by indices of discrimination, reclassification, and calibration.Abstract: RESULTS: After adjustment for standard risk factors, only HbA1c, albuminuria, and left atrial diameter were significantly associated with first ischemic stroke. Addition of HbA1c, although not urine albumin-to-creatinine ratio, to a basic clinical model significantly improved the C-statistic (0.714 versus 0.695; P=0.044), whereas left atrial diameter modestly enhanced integrated discrimination improvement (0.90%; P=0.004), but not the C-statistic (0.701; P=0.528). When combined with HbA1c, left atrial diameter further increased integrated discrimination improvement (1.81%; P<0.001) but not the C-statistic (0.716). No marker achieved significant net reclassification improvement.Abstract: CONCLUSIONS: In this cohort at high cardiometabolic risk, HbA1c emerged as the foremost predictor of ischemic stroke when added to traditional risk factors, affording substantially improved discrimination, with a more modest contribution for left atrial diameter. These findings bolster the role of HbA1c in cardiovascular risk assessment among persons with glycometabolic disorders and provide impetus for further study of the incremental value of echocardiography in high-risk populations.

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