Citation: American Journal of Clinical Nutrition. 95(3):752-8, 2012 Mar..Journal: The American journal of clinical nutrition.ISSN: 0002-9165.Full author list: Fretts AM; Howard BV; McKnight B; Duncan GE; Beresford SA; Mete M; Eilat-Adar S; Zhang Y; Siscovick DS.UI/PMID: 22277554.Subject(s): Adolescent | Adult | Aged | *Diabetes Mellitus/ep [Epidemiology] | Diabetes Mellitus/et [Etiology] | *Diet/ae [Adverse Effects] | *Energy Intake | Female | Follow-Up Studies | Food Handling | Food, Preserved/ae [Adverse Effects] | Humans | Incidence | Indians, North American | Interviews as Topic | Male | *Meat/ae [Adverse Effects] | *Meat Products/ae [Adverse Effects] | Middle Aged | Nutrition Assessment | Prospective Studies | Questionnaires | Risk Factors | Rural Population | United States | Young AdultInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.3945/ajcn.111.029942 (Click here)Abbreviated citation: Am J Clin Nutr. 95(3):752-8, 2012 Mar.Local Holdings: Available online from MWHC library: Sept 1992 - present, Available in print through MWHC library: 1999 - 2006.Abstract: BACKGROUND: Fifty percent of American Indians (AIs) develop diabetes by age 55 y. Whether processed meat is associated with the risk of diabetes in AIs, a rural population with a high intake of processed meat (eg, canned meats in general, referred to as "spam") and a high rate of diabetes, is unknown.Abstract: OBJECTIVE: We examined the associations of usual intake of processed meat with incident diabetes in AIs.Abstract: DESIGN: This prospective cohort study included AI participants from the Strong Heart Family Study who were free of diabetes and cardiovascular disease at baseline and who participated in a 5-y follow-up examination (n = 2001). Dietary intake was ascertained by using a Block food-frequency questionnaire at baseline. Incident diabetes was defined on the basis of 2003 American Diabetes Association criteria. Generalized estimating equations were used to examine the associations of dietary intake with incident diabetes.Abstract: RESULTS: We identified 243 incident cases of diabetes. In a comparison of upper and lower quartiles, intake of processed meat was associated with a higher risk of incident diabetes (OR: 1.63; 95% CI: 1.21, 2.63), after adjustment for potential confounders. The relation was particularly strong for spam (OR for the comparison of upper and lower quartiles: 2.06; 95% CI: 1.30, 3.27). Intake of unprocessed red meat was not associated with incident diabetes (OR for the comparison of upper and lower quartiles: 0.90; 95% CI: 0.59, 1.37).Abstract: CONCLUSION: The consumption of processed meat, such as spam, but not unprocessed red meat, was associated with higher risk of diabetes in AIs, a rural population at high risk of diabetes and with limited access to healthy foods.