MedStar Authors catalog › Details for: Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium.
Citation: Diabetes. 61(6):1642-7, 2012 Jun..Journal: Diabetes.ISSN: 0012-1797.Full author list: Haiman CA; Fesinmeyer MD; Spencer KL; Buzkova P; Voruganti VS; Wan P; Haessler J; Franceschini N; Monroe KR; Howard BV; Jackson RD; Florez JC; Kolonel LN; Buyske S; Goodloe RJ; Liu S; Manson JE; Meigs JB; Waters K; Mukamal KJ; Pendergrass SA; Shrader P; Wilkens LR; Hindorff LA; Ambite JL; North KE; Peters U; Crawford DC; Le Marchand L; Pankow JS.UI/PMID: 22474029.Subject(s): Adult | Aged | Aged, 80 and over | Alleles | Diabetes Mellitus, Type 2/eh [Ethnology] | *Diabetes Mellitus, Type 2/ge [Genetics] | Female | *Genetic Predisposition to Disease | Genome-Wide Association Study | Genotype | Humans | Male | Metagenomics | Middle Aged | *Population Groups/ge [Genetics] | Risk | Risk FactorsInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.2337/db11-1296 (Click here)Abbreviated citation: Diabetes. 61(6):1642-7, 2012 Jun.Local Holdings: Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006.Abstract: Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes across six major racial/ethnic groups in the U.S. as part of the Population Architecture using Genomics and Epidemiology Consortium (16,235 diabetes case and 46,122 control subjects of European American, African American, Hispanic, East Asian, American Indian, and Native Hawaiian ancestry). The percentage of positive (odds ratio [OR] >1 for putative risk allele) associations ranged from 69% in American Indians to 100% in European Americans. Of the nine variants where we observed significant heterogeneity of effect by racial/ethnic group (P(heterogeneity) < 0.05), eight were positively associated with risk (OR >1) in at least five groups. The marked directional consistency of association observed for most genetic variants across populations implies a shared functional common variant in each region. Fine-mapping of all loci will be required to reveal markers of risk that are important within and across populations.