Citation: American Journal of Cardiology. 110(8):1189-94, 2012 Oct 15..Journal: The American journal of cardiology.ISSN: 0002-9149.Full author list: Devereux RB; de Simone G; Arnett DK; Best LG; Boerwinkle E; Howard BV; Kitzman D; Lee ET; Mosley TH Jr; Weder A; Roman MJ.UI/PMID: 22770936.Subject(s): Adolescent | Adult | Aged | *Aging/ph [Physiology] | Analysis of Variance | *Aorta, Thoracic/ah [Anatomy & Histology] | Aorta, Thoracic/us [Ultrasonography] | Body Size | *Echocardiography/mt [Methods] | Female | Humans | Linear Models | Male | Middle Aged | Reference Values | Sex FactorsInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.1016/j.amjcard.2012.05.063 (Click here)Abbreviated citation: Am J Cardiol. 110(8):1189-94, 2012 Oct 15.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: Nomograms to predict normal aortic root diameter for body surface area (BSA) in broad ranges of age have been widely used but are limited by lack of consideration of gender effects, jumps in upper limits of aortic diameter among age strata, and data from older teenagers. Sinus of Valsalva diameter was measured by American Society of Echocardiography convention in normal-weight, nonhypertensive, nondiabetic subjects >=15 years old without aortic valve disease from clinical or population-based samples. Analyses of covariance and linear regression with assessment of residuals identified determinants and developed predictive models for normal aortic root diameter. In 1,207 apparently normal subjects >=15 years old (54% women), aortic root diameter was 2.1 to 4.3 cm. Aortic root diameter was strongly related to BSA and height (r = 0.48 for the 2 comparisons), age (r = 0.36), and male gender (+2.7 mm adjusted for BSA and age, p <0.001 for all comparisons). Multivariable equations using age, gender, and BSA or height predicted aortic diameter strongly (R = 0.674 for the 2 comparisons, p <0.001) with minimal relation of residuals to age or body size: for BSA 2.423 + (age [years] x 0.009) + (BSA [square meters] x 0.461) - (gender [1 = man, 2 = woman] x 0.267), SEE 0.261 cm; for height 1.519 + (age [years] x 0.010) + (height [centimeters] x 0.010) - (gender [1 = man, 2 = woman] x 0.247), SEE 0.215 cm. In conclusion, aortic root diameter is larger in men and increases with body size and age. Regression models incorporating body size, age, and gender are applicable to adolescents and adults without limitations of previous nomograms. Copyright 2012 Elsevier Inc. All rights reserved.