MedStar Authors catalog › Details for: The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.
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The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.

by Howard, Barbara V.
Citation: ; Breast Cancer Research & Treatment. 167(3):741-749, 2018 02..Journal: Breast cancer research and treatment.Published: 2018ISSN: 0167-6806.Full author list: Bock CH; Jay AM; Dyson G; Beebe-Dimmer JL; Cote ML; Hou L; Howard BV; Desai P; Purrington K; Prentice R; Simon MS.UI/PMID: 29063981.Subject(s): Aged | Anticholesteremic Agents/ad [Administration & Dosage] | Anticholesteremic Agents/ae [Adverse Effects] | *Breast Neoplasms/dt [Drug Therapy] | Breast Neoplasms/ge [Genetics] | Breast Neoplasms/pa [Pathology] | *Cholesterol/ge [Genetics] | Cholesterol/me [Metabolism] | Female | *Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | *Hydroxymethylglutaryl-CoA Reductase Inhibitors/ad [Administration & Dosage] | Hydroxymethylglutaryl-CoA Reductase Inhibitors/ae [Adverse Effects] | Middle Aged | Polymorphism, Single Nucleotide/ge [Genetics] | Postmenopause | Risk Assessment | Risk Factors | Women's HealthInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1007/s10549-017-4521-0 (Click here) Abbreviated citation: ; Breast Cancer Res Treat. 167(3):741-749, 2018 02.Local Holdings: Available online from MWHC library: 1997 - present.Abstract: PURPOSE: Statins have been postulated to have chemopreventive activity against breast cancer. We evaluated whether germline genetic polymorphisms modified the relationship between statins and breast cancer risk using data from the Women's Health Initiative. We evaluated these interactions using both candidate gene and agnostic genome-wide approaches.Abstract: METHODS: To identify candidate gene-statin interactions, we tested interactions between 22 SNPS in nine candidate genes implicated in the effect of statins on lipid metabolism in 1687 cases and 1687 controls. We then evaluated statin use interaction with the remaining 30,380 SNPs available in this sample from the CGEMS GWAS study.Abstract: RESULTS: After adjusting for multiple comparisons, no SNP interactions with statin usage and risk of breast cancer were statistically significant in either the candidate genes or genome-wide approaches.Abstract: CONCLUSIONS: We found no evidence of SNP interactions with statin usage for breast cancer risk in a population of 3374 individuals. These results suggest that genome-wide common genetic variants do not moderate the association between statin usage and breast cancer in the population of women in the Women's Health Initiative.

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