MedStar Authors catalog › Details for: A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women.
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A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women.

by Howard, Barbara V.
Citation: Diabetes. 61(11):2998-3004, 2012 Nov..Journal: Diabetes.ISSN: 0012-1797.Full author list: You NC; Chen BH; Song Y; Lu X; Chen Y; Manson JE; Kang M; Howard BV; Margolis KL; Curb JD; Phillips LS; Stefanick ML; Tinker LF; Liu S.UI/PMID: 22829448.Subject(s): Aged | Cohort Studies | Diabetes Mellitus, Type 2/bl [Blood] | Diabetes Mellitus, Type 2/ep [Epidemiology] | Diabetes Mellitus, Type 2/eh [Ethnology] | *Diabetes Mellitus, Type 2/ge [Genetics] | Female | Follow-Up Studies | Genetic Association Studies | Humans | *Leukocytes/me [Metabolism] | Mendelian Randomization Analysis | Middle Aged | Polymerase Chain Reaction | Polymorphism, Single Nucleotide | Postmenopause | Prospective Studies | Risk Factors | *Telomere Shortening | Telomere-Binding Proteins/ge [Genetics] | Telomere-Binding Proteins/me [Metabolism] | United States/ep [Epidemiology]Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.2337/db12-0241 (Click here) Abbreviated citation: Diabetes. 61(11):2998-3004, 2012 Nov.Local Holdings: Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006.Abstract: Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating the role of TL and relevant genes in diabetes development. In the multiethnic Women's Health Initiative, we identified 1,675 incident diabetes case participants in 6 years of follow-up and 2,382 control participants matched by age, ethnicity, clinical center, time of blood draw, and follow-up duration. Leukocyte TL at baseline was measured using quantitative PCR, and Mendelian randomization analysis was conducted to test whether TL is causally associated with diabetes risk. After adjustment for matching and known diabetes risk factors, odds ratios per 1-kilobase increment were 1.00 (95% CI 0.90-1.11) in whites, 0.95 (0.85-1.06) in blacks, 0.96 (0.79-1.17) in Hispanics, and 0.88 (0.70-1.10) in Asians. Of the 80 single nucleotide polymorphisms (SNPs) in nine genes involved in telomere regulation, 14 SNPs were predictive of TL, but none were significantly associated with diabetes risk. Using ethnicity-specific SNPs as randomization instruments, we observed no statistically significant association between TL and diabetes risk (P = 0.52). Although leukocyte TL was weakly associated with diabetes risk, this association was not independent of known risk factors. These prospective findings indicate limited clinical utility of TL in diabetes risk stratification among postmenopausal women.

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