Associations between lipids and subclinical coronary atherosclerosis.

MedStar author(s):
Citation: AIDS. 2019 Jan 16PMID: 30664005Institution: MedStar Union Memorial HospitalDepartment: CardiologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2019ISSN:
  • 0269-9370
Name of journal: AIDS (London, England)Abstract: CONCLUSION: The associations between lipids and coronary atherosclerosis tended to be weaker for HIV+ compared to HIV- men, although TC/HDL had the strongest association for both HIV+ and HIV- men. A weaker association between lipid levels and coronary atherosclerosis for HIV+ men may contribute to the decreased discrimination of CVD risk observed in HIV+ individuals.DESIGN: The Multicenter AIDS Cohort Study (MACS) is an observational cohort with a total of 429 HIV+ and 303 HIV- men who had non-contrast cardiac computed tomography (CT) performed to measure coronary artery calcium (CAC) and coronary CT angiography to measure coronary stenosis, coronary plaque presence, and composition.METHODS: We used multivariable adjusted prevalence ratios (PR) to examine the relationship between the standard deviation (SD) difference in each lipid parameter and coronary atherosclerosis.OBJECTIVE: Whether HIV modifies the relationship of serum lipids with coronary atherosclerosis and coronary plaque subtypes is uncertain. We examined the associations between traditional lipids and coronary atherosclerosis among HIV-infected (HIV+) and HIV-uninfected (HIV-) men.RESULTS: Total cholesterol (TC) / HDL-C had the strongest associations with coronary atherosclerosis regardless of HIV status. Overall, lipid parameters were most strongly associated with the presence of mixed plaque, stenosis >50%, and CAC for both HIV+ and HIV- men. HIV+ men had similar, but weaker associations, between lipid parameters and coronary atherosclerosis compared to HIV- men. The strongest association was between the TC/HDL-C and stenosis >50% for both HIV+ [PR 1.25 per SD (95% CI 1.07-1.43)] and HIV- men [PR 1.46 per SD (95% CI 1.08-1.85)].All authors: Brown TT, Budoff M, Deal JA, Jacobson LP, Kingsley L, Palella FJ Jr, Post WS, Sarkar S, Whelton SP, Witt MD, Zikusoka MFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2019-01-28
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Journal Article MedStar Authors Catalog Article 30664005 Available 30664005

CONCLUSION: The associations between lipids and coronary atherosclerosis tended to be weaker for HIV+ compared to HIV- men, although TC/HDL had the strongest association for both HIV+ and HIV- men. A weaker association between lipid levels and coronary atherosclerosis for HIV+ men may contribute to the decreased discrimination of CVD risk observed in HIV+ individuals.

DESIGN: The Multicenter AIDS Cohort Study (MACS) is an observational cohort with a total of 429 HIV+ and 303 HIV- men who had non-contrast cardiac computed tomography (CT) performed to measure coronary artery calcium (CAC) and coronary CT angiography to measure coronary stenosis, coronary plaque presence, and composition.

METHODS: We used multivariable adjusted prevalence ratios (PR) to examine the relationship between the standard deviation (SD) difference in each lipid parameter and coronary atherosclerosis.

OBJECTIVE: Whether HIV modifies the relationship of serum lipids with coronary atherosclerosis and coronary plaque subtypes is uncertain. We examined the associations between traditional lipids and coronary atherosclerosis among HIV-infected (HIV+) and HIV-uninfected (HIV-) men.

RESULTS: Total cholesterol (TC) / HDL-C had the strongest associations with coronary atherosclerosis regardless of HIV status. Overall, lipid parameters were most strongly associated with the presence of mixed plaque, stenosis >50%, and CAC for both HIV+ and HIV- men. HIV+ men had similar, but weaker associations, between lipid parameters and coronary atherosclerosis compared to HIV- men. The strongest association was between the TC/HDL-C and stenosis >50% for both HIV+ [PR 1.25 per SD (95% CI 1.07-1.43)] and HIV- men [PR 1.46 per SD (95% CI 1.08-1.85)].

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