Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.

MedStar author(s):
Citation: Annals of Clinical & Translational Neurology. 6(4):817-820, 2019 Apr.PMID: 31020007Institution: MedStar Washington Hospital CenterDepartment: NeurologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Brain Ischemia/ge [Genetics] | *Brain/pa [Pathology] | *Cerebrovascular Circulation/ph [Physiology] | *Stroke/ge [Genetics] | Aged | Aged, 80 and over | Brain Ischemia/di [Diagnosis] | Brain/me [Metabolism] | Diffusion Magnetic Resonance Imaging | Female | Humans | Male | Middle Aged | Research Design | Stroke/di [Diagnosis]Year: 2019ISSN:
  • 2328-9503
Name of journal: Annals of clinical and translational neurologyAbstract: We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score -2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.All authors: Benson RT, Hallenbeck JM, Hsia AW, Johnson KR, Kelley D, Latour LL, Leigh R, Luby M, Lynch JK, Nadareishvili Z, Simpkins ANFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2019-05-21
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Journal Article MedStar Authors Catalog Article 31020007 Available 31020007

We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score -2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.

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