MedStar Authors catalog › Details for: Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.
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Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

by Howard, Barbara V.
Citation: PLoS ONE [Electronic Resource]. 9(12):e113203, 2014..Journal: PloS one.ISSN: 1932-6203.Full author list: Franceschini N; Hu Y; Reiner AP; Buyske S; Nalls M; Yanek LR; Li Y; Hindorff LA; Cole SA; Howard BV; Stafford JM; Carty CL; Sethupathy P; Martin LW; Lin DY; Johnson KC; Becker LC; North KE; Dehghan A; Bis JC; Liu Y; Greenland P; Manson JE; Maeda N; Garcia M; Harris TB; Becker DM; O'Donnell C; Heiss G; Kooperberg C; Boerwinkle E.UI/PMID: 25542012.Subject(s): *Adaptor Proteins, Vesicular Transport/ge [Genetics] | *African Americans/ge [Genetics] | Coronary Disease/ep [Epidemiology] | Coronary Disease/eh [Ethnology] | *Coronary Disease/ge [Genetics] | Female | Genetic Association Studies/mt [Methods] | Genetic Predisposition to Disease | Humans | Male | Oligonucleotide Array Sequence Analysis/mt [Methods] | Polymorphism, Single Nucleotide | Prospective Studies | *Proto-Oncogene Proteins c-myc/ge [Genetics]Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Meta-Analysis | Research Support, N.I.H., Extramural | Research Support, N.I.H., Intramural | Research Support, U.S. Gov't, P.H.SOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: PLoS ONE. 9(12):e113203, 2014.Local Holdings: Available online through MWHC library: 2006 - present.Abstract: BACKGROUND: Coronary heart disease (CHD) is a leading cause of morbidity and mortality in African Americans. However, there is a paucity of studies assessing genetic determinants of CHD in African Americans. We examined the association of published variants in CHD loci with incident CHD, attempted to fine map these loci, and characterize novel variants influencing CHD risk in African Americans.Abstract: METHODS AND RESULTS: Up to 8,201 African Americans (including 546 first CHD events) were genotyped using the MetaboChip array in the Atherosclerosis Risk in Communities (ARIC) study and Women's Health Initiative (WHI). We tested associations using Cox proportional hazard models in sex- and study-stratified analyses and combined results using meta-analysis. Among 44 validated CHD loci available in the array, we replicated and fine-mapped the SORT1 locus, and showed same direction of effects as reported in studies of individuals of European ancestry for SNPs in 22 additional published loci. We also identified a SNP achieving array wide significance (MYC: rs2070583, allele frequency 0.02, P = 8.1 x 10(-8)), but the association did not replicate in an additional 8,059 African Americans (577 events) from the WHI, HealthABC and GeneSTAR studies, and in a meta-analysis of 5 cohort studies of European ancestry (24,024 individuals including 1,570 cases of MI and 2,406 cases of CHD) from the CHARGE Consortium.Abstract: CONCLUSIONS: Our findings suggest that some CHD loci previously identified in individuals of European ancestry may be relevant to incident CHD in African Americans.

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