Citation: American Journal of Cardiology. 113(8):1326-30, 2014 Apr 15..Journal: The American journal of cardiology.ISSN: 0002-9149.Full author list: Baker NC; Lipinski MJ; Escarcega RO; Magalhaes MA; Minha S; Torguson R; Waksman R.UI/PMID: 24576542.Subject(s): Aged | *Cardiac Catheterization/ae [Adverse Effects] | District of Columbia/ep [Epidemiology] | Female | Follow-Up Studies | Humans | Incidence | Male | Myocardial Infarction/ep [Epidemiology] | *Myocardial Infarction/et [Etiology] | Prognosis | *Quality Assurance, Health Care | *Registries | Retrospective Studies | *Risk Assessment/mt [Methods] | Risk Factors | Survival Rate/td [Trends]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Clinical Trial | Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.1016/j.amjcard.2014.01.408 (Click here)Abbreviated citation: Am J Cardiol. 113(8):1326-30, 2014 Apr 15.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: A consensus on what constitutes a clinically meaningful periprocedural myocardial infarction (PMI) remains highly debated. We evaluated the accuracy of 2 PMI definitions currently implemented for quality outcome assessment and clinical trial end points. Patients who underwent elective percutaneous coronary intervention with normal baseline troponin-I and creatine kinase-MB were included. PMI was defined according to either the 2007 Task Force (National Cardiovascular Database Registry [NCDR] CathPCI Registry) definition or the updated 2012 Task Force definition. Multivariate analysis was performed for the end point of 1-year all-cause death or myocardial infarction (MI). Of the 7,333 patients included, 31.9% and 2.1% were identified as having a PMI by NCDR or 2012 definition, respectively. Mean age was 66+11 years; 66.8% were men, 1.4+0.9 stents implanted per patient, 84.5% bivalirudin use, and 29.7 type C lesions. Death or MI occurred in 5.6% of NCDR and 6.6% of 2012 defined patients. Neither biomarker was independently associated with death or MI for either definition (NCDR odds ratio 1.1, 95% confidence interval 0.9 to 1.5, p=0.34; 2012 Task Force odds ratio 1.4, 95% confidence interval 0.7 to 3.0, p=0.38). Only a modest correlation exists for either definition to predict death or MI, which did not improve for the 2012 definition. In conclusion, PMI definitions currently used for catheterization lab quality metrics and those used for clinical trial end points have poor discrimination for adverse events. Although the 2012 definition drastically reduced the number of PMIs defined, it did not decrease the predictive accuracy over the NCDR definition. Copyright 2014 Elsevier Inc. All rights reserved.