MedStar Authors catalog › Details for: Association between Lifetime Risk of Atrial Fibrillation and Mortality in the Oldest Old.
Normal view MARC view ISBD view

Association between Lifetime Risk of Atrial Fibrillation and Mortality in the Oldest Old.

by Shara, Nawar M.
Citation: ; Clinical Cardiology. 41(5):634-639, 2018 May..Journal: Clinical cardiology.Published: 2018ISSN: 0160-9289.Full author list: Kheirbek RE; Fokar A; Moore HJ; Shara N; Doukky R; Fletcher RD.UI/PMID: 29566272.Subject(s): Age Factors | Aged | Aged, 80 and over | *Aging | Anticoagulants/tu [Therapeutic Use] | Atrial Fibrillation/di [Diagnosis] | Atrial Fibrillation/dt [Drug Therapy] | *Atrial Fibrillation/mo [Mortality] | Atrial Fibrillation/pp [Physiopathology] | Female | Humans | Incidence | Kaplan-Meier Estimate | Longitudinal Studies | Male | Platelet Aggregation Inhibitors/tu [Therapeutic Use] | Prognosis | Proportional Hazards Models | Protective Factors | Retrospective Studies | Risk Factors | Time Factors | United States/ep [Epidemiology] | United States Department of Veterans Affairs | Veterans HealthInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1002/clc.22941 (Click here) ORCID: Kheirbek, Raya Elfadel http://orcid.org/0000-0003-0755-1940 (Click here) Abbreviated citation: ; Clin Cardiol. 41(5):634-639, 2018 May.Local Holdings: Available online from MWHC library: 1976 - present, Available in print through MWHC library:1999-2007.Abstract: BACKGROUND: Age is the strongest predictor of atrial fibrillation (AF), yet little is known about AF incidence in the oldest old.Abstract: HYPOTHESIS: AF incidence declines after age 90, and morbidity is compressed into a brief period at the end of life.Abstract: METHODS: In this retrospective, longitudinal cohort study of patients (born 1905-1935), we examined cumulative lifetime incidence of AF and its impact on mortality. Data included records from 1,062,610 octogenarians; 317,161 nonagenarians; and 3,572 centenarians. Kaplan-Meier curves were used to estimate cumulative incidence of AF by age group, incidence rates were compared using log-rank tests, and Cox proportional-hazards model were used to estimate unadjusted hazard ratios. The primary outcome was AF incidence at > age 80; the secondary outcome was mortality.Abstract: RESULTS: Cumulative AF incidence rate was 5.0% in octogenarians, 5.4% in nonagenarians, and 2.3% in centenarians. Octogenarians and nonagenarians had a higher risk of AF incidence compared to centenarians (adjusted hazard ratio 8.74; 95% CI [6.31-12.04] and 2.98; 95%CI [2.17-4.1], respectively). The lowest hazard ratio for mortality in patients with AF compared to those without 2.3; 95% CI(2.3-2.4) in patients who are on antiplatelet and anticoagulant medication, and have a score of 0 on the Elixhauser comorbidity index score.Abstract: CONCLUSION: Although AF incidence increased with age, being a centenarian was associated with reduced incidence and compression of morbidity. Patients with AF had a higher adjusted mortality rate. However, data suggests that a regimen of anticoagulant and antiplatelet seems to reduce risk of mortality in patients with AF diagnosis.Abstract: Copyright This article is protected by copyright. All rights reserved.

Powered by Koha