Citation: Cancer Medicine. 2018 Apr 02.Journal: Cancer medicine.Published: 2018ISSN: 2045-7634.Full author list: Desai P; Wallace R; Anderson ML; Howard BV; Ray R; Wu C; Safford M; Martin LW; Schlecht N; Liu S; Cirillo D; Jay A; Manson JE; Simon MS.UI/PMID: 29608241.Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1002/cam4.1368 (Click here)ORCID: Desai, Pinkal http://orcid.org/0000-0002-9816-7284Simon, Michael S http://orcid.org/0000-0002-3237-6761 (Click here) | (Click here)Abbreviated citation: Cancer Med. 2018 Apr 02.Abstract: Statins have been shown to induce a phosphoprotein signature that modifies MYC (myelocytomatosis viral oncogene) activation and to have anti-inflammatory activity that may impact the risk of Non-Hodgkin's lymphoma (NHL). We analyzed the relationship between statins and risk of NHL using data from the Women's Health Initiative (WHI). The study population included 161,563 postmenopausal women ages 50-79 years from which 712 cases of NHL were diagnosed after 10.8 years of follow-up. Information on statin use and other risk factors was collected by self- and interviewer-administered questionnaires. Multivariable-adjusted HR and 95% CI evaluating the relationship between statin use at baseline, as well as in a time-dependent manner and risk of NHL, were computed from Cox proportional hazards analyses. A separate analysis was performed for individual NHL subtypes: diffuse large B-Cell lymphoma (DLBCL) (n = 228), follicular lymphoma (n = 169), and small lymphocytic lymphoma (n = 74). All statistical tests were two-sided. There was no significant association between use of statins at baseline and risk of NHL (HR 0.85, 95% C.I. 0.67-1.08). However, in the multivariable-adjusted time-dependent models, statin use was associated with a borderline lower risk of NHL (HR 0.81, 95% C.I. 0.66-1.00). Considering subtypes of NHL, statin use was associated with a lower risk of DLBCL (HR 0.62, 95% C.I. 0.42-0.91). This effect was driven by lipophilic statins (HR 0.62, 95% C.I. 0.40-0.96). In the WHI, statins were associated with a lower overall risk of DLBCL, particularly attributable to lipophilic statins. These results may have impact on primary or secondary prevention of NHL, particularly DLBCL.Abstract: Copyright (c) 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.