Citation: Journal of Clinical Endocrinology & Metabolism. 103(5):1813-1817, 2018 May 01..Journal: The Journal of clinical endocrinology and metabolism.Published: 2018ISSN: 0021-972X.Full author list: Ylli D; Burman KD; Van Nostrand D; Wartofsky L.UI/PMID: 29741712.Subject(s): *Adenocarcinoma, Follicular/pa [Pathology] | Age Factors | *Aging/ph [Physiology] | *Carcinoma, Papillary/pa [Pathology] | Diagnostic Techniques, Endocrine/st [Standards] | Humans | Neoplasm Staging/mt [Methods] | *Neoplasm Staging/st [Standards] | Prognosis | Reference Values | *Thyroid Neoplasms/pa [Pathology]Institution(s): MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment(s): Medicine/Endocrinology | Medicine/Nuclear MedicineActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1210/jc.2017-02725 (Click here)Abbreviated citation: J Clin Endocrinol Metab. 103(5):1813-1817, 2018 May 01.Local Holdings: Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006.Abstract: Background: Unlike virtually all other cancer types, thyroid cancer is unique in that patient age is a key component in its staging. Pathologists and clinicians worldwide have accepted an age cutoff of 45 years for staging; in 2018, this advances to age 55 years in the eighth edition of the American Joint Commission on Cancer staging system.Abstract: Evidence Acquisition: Clinical and basic research studies, reviews, and previous editions of consensus statements regarding thyroid cancer staging were reviewed, with particular focus on the influence of age in thyroid cancer prognosis.Abstract: Purpose: This perspective briefly reviews the basis for this practice and challenges it as no more appropriate than for other malignancies.Abstract: Evidence Synthesis: The majority of findings report an association of age with thyroid cancer survival but do not support a specific age cutoff; rather, they suggest that outcome is affected by age as a continuous variable. Conceivably, other factors interact with age on a continuous basis over time, affecting prognosis. When identified, these factors could alter our current concept of the importance of an age cutoff in staging.Abstract: Conclusions: Among all cancers, age has an important role in only thyroid cancer staging. The consideration of age as a continuous variable and the search for age-associated prognostic variables could elucidate a more accurate staging system.